The aim of this work is to provide the information needed to adequately apply chimeric antigen receptor T-cell (CAR-T) therapy in real clinical practice in outpatient, day hospital and ward settings, with a particular focus on patients with diffuse large cell lymphoma and mantle cell lymphoma, which currently represent the main area of use of anti-CD19 CAR-T treatment. The currently approved indications in both contexts are reviewed and the fundamental steps to follow in starting CAR-T cell therapy are described, as well as the data available in the literature regarding each previously presented indication.
Broccoli, A., Zinzani, P.L. (2025). Il ruolo attuale del trattamento con cellule CAR-T nella terapia dei linfomi: focus su linfoma diffuso a grandi cellule e linfoma mantellare. RECENTI PROGRESSI IN MEDICINA, 116(5), 272-284 [10.1701/4495.44947].
Il ruolo attuale del trattamento con cellule CAR-T nella terapia dei linfomi: focus su linfoma diffuso a grandi cellule e linfoma mantellare
Broccoli, Alessandro;Zinzani, Pier Luigi
2025
Abstract
The aim of this work is to provide the information needed to adequately apply chimeric antigen receptor T-cell (CAR-T) therapy in real clinical practice in outpatient, day hospital and ward settings, with a particular focus on patients with diffuse large cell lymphoma and mantle cell lymphoma, which currently represent the main area of use of anti-CD19 CAR-T treatment. The currently approved indications in both contexts are reviewed and the fundamental steps to follow in starting CAR-T cell therapy are described, as well as the data available in the literature regarding each previously presented indication.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
