Paraneoplastic neurological syndromes (PNSs) are immune-mediated effects of remote cancer, which often harbor anti-neuronal antibodies. These antibodies may direct toward intracellular or cell-surface antigens and the clinical picture associated with each antibody is often stereotyped. Little is known about clinical and radiological manifestations of PNSs with co-occurring anti-intracellular and anti-surface neuronal antigens. This case report describes a unique case of a patient with small cell lung cancer harboring both anti-GABABR and anti-Hu antibodies who presented with multifocal encephalitis, manifesting with status epilepticus and epilepsia partialis continua.
Viola, V., Asioli, G.M., Ferri, L., Rossi, S., Andrini, E., Pierucci, E., et al. (2025). Multifocal paraneoplastic encephalitis associated with anti-GABA-B and anti-Hu antibodies manifesting with status epilepticus and epilepsia partialis continua: Expanding the clinical-radiological spectrum. JOURNAL OF NEUROIMMUNOLOGY, 405, 1-5 [10.1016/j.jneuroim.2025.578634].
Multifocal paraneoplastic encephalitis associated with anti-GABA-B and anti-Hu antibodies manifesting with status epilepticus and epilepsia partialis continua: Expanding the clinical-radiological spectrum
Viola V.;Asioli G. M.;Ferri L.;Rossi S.;Andrini E.;Pierucci E.;Lamberti G.;Sambati L.;Bisulli F.;Spinardi L.;
2025
Abstract
Paraneoplastic neurological syndromes (PNSs) are immune-mediated effects of remote cancer, which often harbor anti-neuronal antibodies. These antibodies may direct toward intracellular or cell-surface antigens and the clinical picture associated with each antibody is often stereotyped. Little is known about clinical and radiological manifestations of PNSs with co-occurring anti-intracellular and anti-surface neuronal antigens. This case report describes a unique case of a patient with small cell lung cancer harboring both anti-GABABR and anti-Hu antibodies who presented with multifocal encephalitis, manifesting with status epilepticus and epilepsia partialis continua.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
