Background: Sleep disorders and neurodegeneration (NDG) are mutually related but the nature of this relationship is unclear. We aimed to better understand the relationship betweensleepandneurodegenerativediseasebyperforming a critical review of epidemiological studies that investigated the association of sleep disorders and the subsequent de velopment of Alzheimer'sdisease (AD), Parkinson'sdisease (PD), or general dementia. Methods: We searched for all case control or prospective cohort studies published in PubMed until August 8 2024 evaluating a series of sleep features and subsequent development of AD, PD, or general dementia over certain observation periods. Patient data, sleep features, and outcome data related to PD, AD, and general dementia wereextractedfollowingthe PRISMAguidelines. Relative risks for the different NDG diseases were extracted. Study quality was assessed with the Newcastle-Ottawa quality assessment scale. Results: Of 1,139 identified articles 52 were selected from30independent studies (29 cohort and onecase-control study), including > 2.9 million individuals with follow-up periods ranging from 3 to 40 years. The included articles reported on 18,765 AD outcomes, 14,312 PD outcomes, and 100,453 dementiaoutcomes.Forty-fivearticleswereclassified as having a high-quality. Despite that, there was a great variability in the main aim of the studies, the sleep features evaluated, the diagnostic system employed, or the duration of the follow-ups. Only twelve studies assessed sleep with objective measures. The influence of sleep duration and sleep quality, chronotype, and the presence of excessive daytime sleepiness, insomnia, obstructive sleep apnea, snoring, restless legs syndrome showed varying risk ratios or no statistically significant association with PD, AD, and dementia over time. Conclusion: Our systematic review un derlines the need for further comprehensive epidemiological studies with homogenous and objective sleep measures to evaluate the different sleep features and understand the relationship between sleep and NDG disease.
Bergmann, M., Tschiderer, L., Seekircher, L., Santamaria, J., Provini, F. (2025). The Complex Interplay between Sleep and Neurodegenerative Diseases: An Epidemiological View. NEUROEPIDEMIOLOGY, n.a., 1-28 [10.1159/000546316].
The Complex Interplay between Sleep and Neurodegenerative Diseases: An Epidemiological View
Provini F.
2025
Abstract
Background: Sleep disorders and neurodegeneration (NDG) are mutually related but the nature of this relationship is unclear. We aimed to better understand the relationship betweensleepandneurodegenerativediseasebyperforming a critical review of epidemiological studies that investigated the association of sleep disorders and the subsequent de velopment of Alzheimer'sdisease (AD), Parkinson'sdisease (PD), or general dementia. Methods: We searched for all case control or prospective cohort studies published in PubMed until August 8 2024 evaluating a series of sleep features and subsequent development of AD, PD, or general dementia over certain observation periods. Patient data, sleep features, and outcome data related to PD, AD, and general dementia wereextractedfollowingthe PRISMAguidelines. Relative risks for the different NDG diseases were extracted. Study quality was assessed with the Newcastle-Ottawa quality assessment scale. Results: Of 1,139 identified articles 52 were selected from30independent studies (29 cohort and onecase-control study), including > 2.9 million individuals with follow-up periods ranging from 3 to 40 years. The included articles reported on 18,765 AD outcomes, 14,312 PD outcomes, and 100,453 dementiaoutcomes.Forty-fivearticleswereclassified as having a high-quality. Despite that, there was a great variability in the main aim of the studies, the sleep features evaluated, the diagnostic system employed, or the duration of the follow-ups. Only twelve studies assessed sleep with objective measures. The influence of sleep duration and sleep quality, chronotype, and the presence of excessive daytime sleepiness, insomnia, obstructive sleep apnea, snoring, restless legs syndrome showed varying risk ratios or no statistically significant association with PD, AD, and dementia over time. Conclusion: Our systematic review un derlines the need for further comprehensive epidemiological studies with homogenous and objective sleep measures to evaluate the different sleep features and understand the relationship between sleep and NDG disease.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
