Synthesis of poly(PDL-GA) copolymers is successfully achieved via enzymatic catalysis starting from omega-pentadecalactone and ethyl glycolate. In the copolymers PDL and GA units show a significant tendency to an alternating arrangement. All copolyesters display a high degree of crystallinity (χc ≈70%) regardless of their composition (GA content: 0-27 mol%). Analysis of melting point depression by the Wendling-Suter model suggests inclusion of GA units in PPDL-type crystals. Accordingly WAXS results show that, with increasing GA unit content, the PPDL unit cell undergoes a gradual increase of c-axis (chain axis) periodicity, compatible with the insertion of GA units within the crystallizing PDL sequences. Poly(PDL-GA) copolymers combine typically hydrophobic (PDL) and hydrophilic (GA) monomers and are promising new tuneable drug-delivery systems for medical applications. In this perspective, poly(PDL-GA) nanoparticles are fabricated and characterized

Copolymers of Ethyl Glycolate and omega–Pentadecalactone: Enzymatic Synthesis and Solid-State Characterization

MAZZOCCHETTI, LAURA;SCANDOLA, MARIASTELLA;
2011

Abstract

Synthesis of poly(PDL-GA) copolymers is successfully achieved via enzymatic catalysis starting from omega-pentadecalactone and ethyl glycolate. In the copolymers PDL and GA units show a significant tendency to an alternating arrangement. All copolyesters display a high degree of crystallinity (χc ≈70%) regardless of their composition (GA content: 0-27 mol%). Analysis of melting point depression by the Wendling-Suter model suggests inclusion of GA units in PPDL-type crystals. Accordingly WAXS results show that, with increasing GA unit content, the PPDL unit cell undergoes a gradual increase of c-axis (chain axis) periodicity, compatible with the insertion of GA units within the crystallizing PDL sequences. Poly(PDL-GA) copolymers combine typically hydrophobic (PDL) and hydrophilic (GA) monomers and are promising new tuneable drug-delivery systems for medical applications. In this perspective, poly(PDL-GA) nanoparticles are fabricated and characterized
L. Mazzocchetti; M. Scandola; Z. Jiang
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/102542
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