Synthesis of poly(PDL-GA) copolymers is successfully achieved via enzymatic catalysis starting from omega-pentadecalactone and ethyl glycolate. In the copolymers PDL and GA units show a significant tendency to an alternating arrangement. All copolyesters display a high degree of crystallinity (χc ≈70%) regardless of their composition (GA content: 0-27 mol%). Analysis of melting point depression by the Wendling-Suter model suggests inclusion of GA units in PPDL-type crystals. Accordingly WAXS results show that, with increasing GA unit content, the PPDL unit cell undergoes a gradual increase of c-axis (chain axis) periodicity, compatible with the insertion of GA units within the crystallizing PDL sequences. Poly(PDL-GA) copolymers combine typically hydrophobic (PDL) and hydrophilic (GA) monomers and are promising new tuneable drug-delivery systems for medical applications. In this perspective, poly(PDL-GA) nanoparticles are fabricated and characterized
Copolymers of Ethyl Glycolate and omega–Pentadecalactone: Enzymatic Synthesis and Solid-State Characterization / L. Mazzocchetti; M. Scandola; Z. Jiang. - In: EUROPEAN POLYMER JOURNAL. - ISSN 0014-3057. - STAMPA. - 47:(2011), pp. 942-948. [10.1016/j.eurpolymj.2011.01.003]
Copolymers of Ethyl Glycolate and omega–Pentadecalactone: Enzymatic Synthesis and Solid-State Characterization
MAZZOCCHETTI, LAURA;SCANDOLA, MARIASTELLA;
2011
Abstract
Synthesis of poly(PDL-GA) copolymers is successfully achieved via enzymatic catalysis starting from omega-pentadecalactone and ethyl glycolate. In the copolymers PDL and GA units show a significant tendency to an alternating arrangement. All copolyesters display a high degree of crystallinity (χc ≈70%) regardless of their composition (GA content: 0-27 mol%). Analysis of melting point depression by the Wendling-Suter model suggests inclusion of GA units in PPDL-type crystals. Accordingly WAXS results show that, with increasing GA unit content, the PPDL unit cell undergoes a gradual increase of c-axis (chain axis) periodicity, compatible with the insertion of GA units within the crystallizing PDL sequences. Poly(PDL-GA) copolymers combine typically hydrophobic (PDL) and hydrophilic (GA) monomers and are promising new tuneable drug-delivery systems for medical applications. In this perspective, poly(PDL-GA) nanoparticles are fabricated and characterizedI documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
