The enantioselective aldol reaction of glycinates with aldehydes — a direct entry to an important class of noncanonical amino acids — has so far eluded small-molecule catalysis. Now, mimicking the cofactor of threonine aldolase enzymes, a chiral carbonyl catalyst that is remarkably effective for this reaction has been developed. This asymmetric protocol has been successfully applied to more than a thousand aldehyde substrates.
Bernardi, L. (2025). Biomimetic aldol reaction of glycinate. NATURE CATALYSIS, 8, 627-628 [10.1038/s41929-025-01383-w].
Biomimetic aldol reaction of glycinate
Bernardi, Luca
2025
Abstract
The enantioselective aldol reaction of glycinates with aldehydes — a direct entry to an important class of noncanonical amino acids — has so far eluded small-molecule catalysis. Now, mimicking the cofactor of threonine aldolase enzymes, a chiral carbonyl catalyst that is remarkably effective for this reaction has been developed. This asymmetric protocol has been successfully applied to more than a thousand aldehyde substrates.File in questo prodotto:
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MS_JSV_1749712055_55_Postprint.pdf
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