Anticipatory postural adjustments (APA) for step initiation were investigated in subjects with Parkinson’s disease (PD) before and six months after surgery for implant of electrodes for Deep Brain Stimulation (DBS). APA were found impaired in PD and ameliorated by levodopa before surgery. Our results showed that six months of DBS impaired step initiation and pre surgery conditions were not restored after surgery even in the optimal subject treatment state. Our results may add insight into the clinical evaluation of DBS and into the knowledge of functional mechanisms of DBS and of neural circuits damaged by PD.
L. Rocchi, L. Chiari, P. Carlson-Kuhta, L. Palmerini, F. B. Horak (2010). Effect of Deep Brain Stimulation on step initiation in subjects with Parkinson’s disease. s.l : s.n.
Effect of Deep Brain Stimulation on step initiation in subjects with Parkinson’s disease
ROCCHI, LAURA;CHIARI, LORENZO;PALMERINI, LUCA;
2010
Abstract
Anticipatory postural adjustments (APA) for step initiation were investigated in subjects with Parkinson’s disease (PD) before and six months after surgery for implant of electrodes for Deep Brain Stimulation (DBS). APA were found impaired in PD and ameliorated by levodopa before surgery. Our results showed that six months of DBS impaired step initiation and pre surgery conditions were not restored after surgery even in the optimal subject treatment state. Our results may add insight into the clinical evaluation of DBS and into the knowledge of functional mechanisms of DBS and of neural circuits damaged by PD.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
