Anticipatory postural adjustments (APA) for step initiation were investigated in subjects with Parkinson’s disease (PD) before and six months after surgery for implant of electrodes for Deep Brain Stimulation (DBS). APA were found impaired in PD and ameliorated by levodopa before surgery. Our results showed that six months of DBS impaired step initiation and pre surgery conditions were not restored after surgery even in the optimal subject treatment state. Our results may add insight into the clinical evaluation of DBS and into the knowledge of functional mechanisms of DBS and of neural circuits damaged by PD.

Effect of Deep Brain Stimulation on step initiation in subjects with Parkinson’s disease

ROCCHI, LAURA;CHIARI, LORENZO;PALMERINI, LUCA;
2010

Abstract

Anticipatory postural adjustments (APA) for step initiation were investigated in subjects with Parkinson’s disease (PD) before and six months after surgery for implant of electrodes for Deep Brain Stimulation (DBS). APA were found impaired in PD and ameliorated by levodopa before surgery. Our results showed that six months of DBS impaired step initiation and pre surgery conditions were not restored after surgery even in the optimal subject treatment state. Our results may add insight into the clinical evaluation of DBS and into the knowledge of functional mechanisms of DBS and of neural circuits damaged by PD.
Proc. 1st International Conference on Applied Bionics and Biomechanics, ICABB 2010
11
15
L. Rocchi; L. Chiari; P. Carlson-Kuhta; L. Palmerini; F. B. Horak
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/101510
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