Systemic Scytalidium Infection with Hyperbetaglobulinemia in a Giant Schnauzer

Scytalidiosis in humans primarily causes feet and nail infections, with systemic infections rarely reported. In dogs, only one systemic infection of Scytalidium spp. has been reported to date. A 3-year-old giant schnauzer presented with loss of appetite, lethargy, and hind limb lameness. A complete clinical examination was performed, along with hematobiochemical tests, radiography, CT, MRI, and cytological and microbiological analyses of it enlarged lymph nodes. Hyperglobulinemia, vertebral osteolysis, and generalized lymphadenomegaly were diagnosed. Cytopathological and molecular investigations confirmed Scytalidium. Although treated with itraconazole, the dog's condition worsened after a premature discontinuation of therapy, leading to euthanasia. A post-mortem and histopathological examination revealed widespread infection. This case highlights the need to consider fungal infections in cases of elevated beta-2 protein.