We recently demonstrated the feasibility of the application of an electrical impedance measurement (IntraValvular Impedance, IVI) to biological heart valves (BHVs) for the monitoring of the valve condition after implant. In this study, we investigate the IVI sensing applied to a BHV when it is surrounded by biological tissue, similar to what happens in vivo. A commercial model of BHV was sensorized with three miniaturized electrodes embedded in the commissures of the valve leaflets and connected to an external impedance measurement unit. The sensorized BHV was implanted in the aortic position of an explanted porcine heart, which was connected to the LifeTec Group's Cardiac BioSimulator to perform ex vivo tests. For each pair of electrodes, the maximum percent variation of the IVI signal was evaluated and compared. The results demonstrate a detectable variation of the IVI signal when the sensorized BHV is surrounded by biological tissue, which is comparable to that we previously obtained in in vitro tests using a polymeric housing for the sensorized BHV.
Gironi, C., Cercenelli, L., Bortolani, B., Emiliani, N., Tartarini, L., Marcelli, E. (2023). Ex Vivo Animal Evaluation of IntraValvular Impedance Sensing Applied to Biological Heart Valve Prostheses. Patron Editore S.r.l..
Ex Vivo Animal Evaluation of IntraValvular Impedance Sensing Applied to Biological Heart Valve Prostheses
Gironi C.Primo
;Cercenelli L.Secondo
;Bortolani B.;Emiliani N.;Tartarini L.Penultimo
;Marcelli E.Ultimo
2023
Abstract
We recently demonstrated the feasibility of the application of an electrical impedance measurement (IntraValvular Impedance, IVI) to biological heart valves (BHVs) for the monitoring of the valve condition after implant. In this study, we investigate the IVI sensing applied to a BHV when it is surrounded by biological tissue, similar to what happens in vivo. A commercial model of BHV was sensorized with three miniaturized electrodes embedded in the commissures of the valve leaflets and connected to an external impedance measurement unit. The sensorized BHV was implanted in the aortic position of an explanted porcine heart, which was connected to the LifeTec Group's Cardiac BioSimulator to perform ex vivo tests. For each pair of electrodes, the maximum percent variation of the IVI signal was evaluated and compared. The results demonstrate a detectable variation of the IVI signal when the sensorized BHV is surrounded by biological tissue, which is comparable to that we previously obtained in in vitro tests using a polymeric housing for the sensorized BHV.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
