The “Woundosome” Concept and Its Impact on Procedural Outcomes in Patients With Chronic Limb-Threatening Ischemia

Patrone, L.; Pasqui, E.; Conte, M. S.; Farber, A.; Ferraresi, R.; Menard, M.; Mills, J. L.; Rundback, J.; Schneider, P.; Ysa, A.; Abhishek, K.; Adams, G. L.; Ahmad, N.; Ahmed, I.; Alexandrescu, V. A.; Amor, M.; Alper, D.; Andrassy, M.; Attinger, C.; Baadh, A.; Barakat, H.; Biasi, L.; Bisdas, T.; Bhatti, Z.; Blessing, E.; Bonaca, M. P.; Bonvini, S.; Bosiers, M.; Bradbury, A. W.; Beasley, R.; Behrendt, C. -A.; Brodmann, M.; Cabral, G.; Cancellieri, R.; Casini, A.; Chandra, V.; Chisci, E.; Chohan, O.; Choke, E. T. C.; Chong, P. F. S.; Clerici, G.; Coscas, R.; Costantino, M.; Dalla Paola, L.; Dand, S.; Davies, R. S. M.; D'Oria, M.; Diamantopoulos, A.; Debus, S.; Deloose, K.; Del Giudice, C.; Donato, G. D.; Rubertis, B. D.; Paul De Vries, J.; Dias, N. V.; Diaz-Sandoval, L.; Dick, F.; Donas, K.; Dua, A.; Fanelli, F.; Fazzini, S.; Foteh, M.; Gandini, R.; Gargiulo, M.; Garriboli, L.; Genovese, E. A.; Gifford, E.; Goueffic, Y.; Goverde, P.; Chand Gupta, P.; Hinchliffe, R.; Holden, A.; Houlind, K. C.; Howard, D. P. J.; Huasen, B.; Isernia, G.; Katsanos, K.; Katzen, B.; Kolh, P.; Koncar, I.; Korosoglou, G.; Krishnan, P.; Kroencke, T.; Krokidis, M.; Kumarasamy, A.; Hayes, P.; Iida, O.; Alejandre Lafont, E.; Langhoff, R.; Lecis, A.; Lessne, M.; Lichaa, H.; Lichtenberg, M.; Lobato, M.; Lopes, A.; Loreni, G.; Lucatelli, P.; Madassery, S.; Maene, L.; Manzi, M.; Maresch, M.; Santhosh Mathews, J.; Mccaslin, J.; Micari, A.; Michelagnoli, S.; Migliara, B.; Morgan, R.; Morelli, L.; Morosetti, D.; Mouawad, N.; Moxey, P.; Muller-Hulsbeck, S.; Mustapha, J.; Nakama, T.; Nasr, B.; N'Dandu, Z.; Neville, R.; Noory, E.; Nordanstig, J.; Noronen, K.; Mariano Palena, L.; Parlani, G.; Patel, A. S.; Patel, P.; Patel, R.; Patel, S.; Pena, C.; Perkov, D.; Portou, M.; Pratesi, G.; Rammos, C.; Reekers, J.; Riambau, V.; Roy, T.; Rosenfield, K.; Antonella Ruffino, M.; Saab, F.; Saratzis, A.; Sbarzaglia, P.; Schmidt, A.; Secemsky, E.; Siah, M.; Sillesen, H.; Simonte, G.; Sirvent, M.; Sommerset, J.; Steiner, S.; Sakr, A.; Scheinert, D.; Shishebor, M.; Spiliopoulos, S.; Spinelli, A.; Stravoulakis, K.; Taneva, G.; Teso, D.; Tessarek, J.; Theivacumar, S.; Thomas, A.; Thomas, S.; Thulasidasan, N.; Torsello, G.; Tripathi, R.; Troisi, N.; Tummala, S.; Tummala, V.; Twine, C.; Uberoi, R.; Ucci, A.; Valenti, D.; Van Den Berg, J.; Van Den Heuvel, D.; Van Herzeele, I.; Varcoe, R.; Vega De Ceniga, M.; Veith, F. J.; Venermo, M.; Vijaynagar, B.; Virdee, S.; Von Stempel, C.; Voute, M. T.; Khee Yeung, K.; Zeller, T.; Zayed, H.; Montero Baker, M.

doi:10.1177/15266028241231745

An important primary emphasis of future trials should be on validating technologies and strategies for assessing tissue perfusion before, during, and after revascularization undertaken to heal tissue loss in CLTI patients. This will allow determination of a potentially significant delta in tissue perfusion prior to and following intervention at the “woundosome” level. Once changes in arterial perfusion have been identified as positively correlated to wound healing, these could serve as a much-needed novel primary technical outcome measure for patients with tissue loss undergoing surgical, hybrid, or endovascular revascularization

Patrone, L., Pasqui, E., Conte, M.S., Farber, A., Ferraresi, R., Menard, M., et al. (2024). The “Woundosome” Concept and Its Impact on Procedural Outcomes in Patients With Chronic Limb-Threatening Ischemia. JOURNAL OF ENDOVASCULAR THERAPY, -, 1-12 [10.1177/15266028241231745].