New swellable micromatrices of α,β-polyasparthydrazide (PAHy) crosslinked with glutaraldehyde were prepared. The effect of crosslinking agent concentration was evaluated. In particular, crosslinking density affected aqueous dynamic swelling and glass-transition temperature of the material. The structure of prepared networks was also studied by scanning electron microscopy and X-ray analysis. Finally, biocompatibility of PAHy derivatives was investigated in vivo by subcutaneous implantation and in oral administration to laboratory animals.
Giammona, G., Pitarresi, G., Tomarchio, V., Spampinato, S., Govoni, P., Campana, G. (1996). International journal of pharmaceutics 127 (1996) 165-175 new hydrogel matrices based on chemical crosslinked α,β-polyasparthydrazide: Synthesis, characterization and in vivo biocompati-bility studies. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 127(2), 165-175 [10.1016/0378-5173(95)04123-0].
International journal of pharmaceutics 127 (1996) 165-175 new hydrogel matrices based on chemical crosslinked α,β-polyasparthydrazide: Synthesis, characterization and in vivo biocompati-bility studies
Spampinato S.;Campana G.
1996
Abstract
New swellable micromatrices of α,β-polyasparthydrazide (PAHy) crosslinked with glutaraldehyde were prepared. The effect of crosslinking agent concentration was evaluated. In particular, crosslinking density affected aqueous dynamic swelling and glass-transition temperature of the material. The structure of prepared networks was also studied by scanning electron microscopy and X-ray analysis. Finally, biocompatibility of PAHy derivatives was investigated in vivo by subcutaneous implantation and in oral administration to laboratory animals.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
