In this hypothesis article, the potential clinicopathological associations of Calcitonin Gene Related Peptide (CGRP) with the development of synuclein-associated neurodegenerative disorders (SAND) are discussed. The presence of α-syn and CGRP in the CNS and the ENS and the intricate role of CGRP and its related pathways in inflammation, apoptosis, metabolism, neuromodulation, and brain-gut communication are analyzed. Since this hypothesis is confirmed, modulating CGRP-potential related pathways may lead to novel disease-modifying therapies.

Alexoudi, A., Donadio, V., Karageorgiou, E. (2024). The potential role of CGRP in synuclein-associated neurodegenerative disorders. FRONTIERS IN NEUROSCIENCE, 18, 39568667-39568667 [10.3389/fnins.2024.1479830].

The potential role of CGRP in synuclein-associated neurodegenerative disorders

Donadio, Vincenzo;
2024

Abstract

In this hypothesis article, the potential clinicopathological associations of Calcitonin Gene Related Peptide (CGRP) with the development of synuclein-associated neurodegenerative disorders (SAND) are discussed. The presence of α-syn and CGRP in the CNS and the ENS and the intricate role of CGRP and its related pathways in inflammation, apoptosis, metabolism, neuromodulation, and brain-gut communication are analyzed. Since this hypothesis is confirmed, modulating CGRP-potential related pathways may lead to novel disease-modifying therapies.
2024
Alexoudi, A., Donadio, V., Karageorgiou, E. (2024). The potential role of CGRP in synuclein-associated neurodegenerative disorders. FRONTIERS IN NEUROSCIENCE, 18, 39568667-39568667 [10.3389/fnins.2024.1479830].
Alexoudi, Athanasia; Donadio, Vincenzo; Karageorgiou, Elissaios
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/1007926
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