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EnglishThe natural diamine putrescine and polyamines spermidine and spermine belong to a family of low-molecularweight organic polycations that are classically known to be important mediators of cell growth, proliferation and division. Several studies are nowadays available about the involvement of polyamines in various aspects - such as growth, differentiation and death - of cardiac cells, under physiological and pathological conditions. Polyamine metabolism and effects, and their relation with a number of extracellular signals and intracellular transductional cascades, have been investigated in cellular and animal models - comprising cultures of embryo, neonatal and adult primary cardiomyocytes, heart-derived cell lines, and stem cells, as well as wild-type and transgenic animals. Significant evidence for their critical role in (mal)adaptive cardiac (patho)physiology emerges from this extensive literature suggesting that, in principle, polyamine metabolism may constitute a target for treatment of cardiovascular di seases. In the present paper we have reviewed these studies.
| Titolo: | Polyamines in cardiac physiology and disease. |
| Autore/i: | GIORDANO, EMANUELE DOMENICO; FLAMIGNI, FLAVIO; GUARNIERI, CARLO; MUSCARI, CLAUDIO; PIGNATTI, CARLA; STEFANELLI, CLAUDIO; TANTINI, BENEDETTA; Caldarera C. M. |
| Autore/i Unibo: | |
| Anno: | 2010 |
| Rivista: | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.2174/1876535101003020025 |
| Abstract: | The natural diamine putrescine and polyamines spermidine and spermine belong to a family of low-molecularweight organic polycations that are classically known to be important mediators of cell growth, proliferation and division. Several studies are nowadays available about the involvement of polyamines in various aspects - such as growth, differentiation and death - of cardiac cells, under physiological and pathological conditions. Polyamine metabolism and effects, and their relation with a number of extracellular signals and intracellular transductional cascades, have been investigated in cellular and animal models - comprising cultures of embryo, neonatal and adult primary cardiomyocytes, heart-derived cell lines, and stem cells, as well as wild-type and transgenic animals. Significant evidence for their critical role in (mal)adaptive cardiac (patho)physiology emerges from this extensive literature suggesting that, in principle, polyamine metabolism may constitute a target for treatment of cardiovascular di seases. In the present paper we have reviewed these studies. |
| Data prodotto definitivo in UGOV: | 2011-02-28 13:41:06 |
| Appare nelle tipologie: | 1.01 Articolo in rivista |
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