Therapeutic Drug Monitoring (TDM) is an evidence-based practice consistent with the assumption that pharmacological plasmatic concentrations correlate better with clinical effects than prescribed doses of the used drugs. TDM has several indications in treated psychiatry patients: comorbidities, suspected non-compliance, severe adverse effects and tailored pharmacotherapy. Antidepressant Drugs (AD) are prescribed in patients with Eating Disorders (ED) to treat depression or anxiety disorders associated with ED or to reduce binge-eating behaviours. TDM may represent a valid tool in this population, considering the limited efficacy of ED’s pharmacological treatment and the high rate of adverse effects. Nineteen outpatients affected by ED with a Body Mass Index (BMI) < 20 or > 30 kg/m2 treated with antidepressants agreed to participate in this study. Participants were treated with Sertraline (N=5), Fluoxetine (N=6), Vortioxetine (N=4), Citalopram (N=2), Escitalopram (N=1), Fluvoxamine (N=1). Oral fluid samples and whole blood dried microsamples by finger puncture using VAMS (Volumetric Absorptive Microsampling) technique were obtained from patients. Sociodemographic and clinical information were also collected.
Panariello, F., Mastellari, T., Di Gianni, A., Speciani, M., De Ronchi, D., Atti, A.r. (2020). Antidepressant Therapeutic Drug Monitoring by Minimally Invasive Techniques in Eating Disorders Patients: Preliminary Results from a Pilot Study with Focus on Vortioxetine. BIOMEDICAL JOURNAL OF SCIENTIFIC & TECHNICAL RESEARCH, 31(5), 24512-24522.
Antidepressant Therapeutic Drug Monitoring by Minimally Invasive Techniques in Eating Disorders Patients: Preliminary Results from a Pilot Study with Focus on Vortioxetine
Panariello F;Mastellari T;Di Gianni A;Speciani M;De Ronchi D;Atti AR
2020
Abstract
Therapeutic Drug Monitoring (TDM) is an evidence-based practice consistent with the assumption that pharmacological plasmatic concentrations correlate better with clinical effects than prescribed doses of the used drugs. TDM has several indications in treated psychiatry patients: comorbidities, suspected non-compliance, severe adverse effects and tailored pharmacotherapy. Antidepressant Drugs (AD) are prescribed in patients with Eating Disorders (ED) to treat depression or anxiety disorders associated with ED or to reduce binge-eating behaviours. TDM may represent a valid tool in this population, considering the limited efficacy of ED’s pharmacological treatment and the high rate of adverse effects. Nineteen outpatients affected by ED with a Body Mass Index (BMI) < 20 or > 30 kg/m2 treated with antidepressants agreed to participate in this study. Participants were treated with Sertraline (N=5), Fluoxetine (N=6), Vortioxetine (N=4), Citalopram (N=2), Escitalopram (N=1), Fluvoxamine (N=1). Oral fluid samples and whole blood dried microsamples by finger puncture using VAMS (Volumetric Absorptive Microsampling) technique were obtained from patients. Sociodemographic and clinical information were also collected.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
