Lithium efficacy is, at least partially, under genetic control. We investigated the association between markers in BDNF and lithium prophylactic efficacy. A set of 10 SNPs within BDNF were genotyped in a sample of 83 bipolar patients. Response to lithium was assessed by presence or absence of any illness phases during a period of 3 years of longitudinal observation. No significant association was detected between the genetic variants tested in BDNF and lithium prophylaxis. Despite the negative association, limitations including small sample size suggest that larger scale genetic associations studies of these genes and lithium prophylaxis are nonetheless indicated. © Informa UK Ltd. 2010.
Drago, A., Serretti, A., Smith, R., Huezo-Diaz, P., Malitas, P., Albani, D., et al. (2010). No association between genetic markers inBDNFgene and lithium prophylaxis in a Greek sample. INTERNATIONAL JOURNAL OF PSYCHIATRY IN CLINICAL PRACTICE, 14(2), 154-157 [10.3109/13651501003706717].
No association between genetic markers inBDNFgene and lithium prophylaxis in a Greek sample
Drago, Antonio;Serretti, Alessandro;Ronchi, Diana DeSupervision
;
2010
Abstract
Lithium efficacy is, at least partially, under genetic control. We investigated the association between markers in BDNF and lithium prophylactic efficacy. A set of 10 SNPs within BDNF were genotyped in a sample of 83 bipolar patients. Response to lithium was assessed by presence or absence of any illness phases during a period of 3 years of longitudinal observation. No significant association was detected between the genetic variants tested in BDNF and lithium prophylaxis. Despite the negative association, limitations including small sample size suggest that larger scale genetic associations studies of these genes and lithium prophylaxis are nonetheless indicated. © Informa UK Ltd. 2010.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
