We have investigated the effect of dye distribution on the electrochemiluminescence (ECL) intensity measured with a simplified magnetic bead-based immunoassay for two families of silica nanoparticles (NPs) doped with the cationic Ru(bpy)32+ and the zwitterionic Ru(bpy)2bps complexes (bps = bathophenanthroline disulfonate). The NPs doped with the Ru(bpy)2bps complex, which can efficiently self-organize in the NP volume favoring ECL generation, resulted in 150-400% signal enhancement compared to the Ru(bpy)32+-doped ones.
Alemu, Y.A., Difonzo, M., Genovese, D., Paolucci, F., Prodi, L., Rampazzo, E., et al. (2024). Dye self-organization in doped silica nanoparticles increases the electrochemiluminescence emission in magnetic bead-based assays. CHEMICAL COMMUNICATIONS, 60(83), 11936-11939 [10.1039/d4cc03488k].
Dye self-organization in doped silica nanoparticles increases the electrochemiluminescence emission in magnetic bead-based assays
Alemu Y. A.;Difonzo M.;Genovese D.;Paolucci F.;Prodi L.;Rampazzo E.;Valenti G.
2024
Abstract
We have investigated the effect of dye distribution on the electrochemiluminescence (ECL) intensity measured with a simplified magnetic bead-based immunoassay for two families of silica nanoparticles (NPs) doped with the cationic Ru(bpy)32+ and the zwitterionic Ru(bpy)2bps complexes (bps = bathophenanthroline disulfonate). The NPs doped with the Ru(bpy)2bps complex, which can efficiently self-organize in the NP volume favoring ECL generation, resulted in 150-400% signal enhancement compared to the Ru(bpy)32+-doped ones.| File | Dimensione | Formato | |
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