The prostaglandin intermediate 2-(6-methoxycarbonylhexyl)-cyclopent-2-en-1-one (5) has been prepared by a short synthetic sequence, consisting of the reaction of 2-(1,3-dioxolan-2-yl)-ethylmagnesium bromide (1) with methyl 9-chloro-9-oxononanoate (2), followed by cleavage of the dioxolane ring of 3 and base-induced cyclisation of 4.
Boga, C., Savoia, D., Trombini, C., Umani-Ronchi, A. (1986). A Short Route to 2-(6-Methoxycarbonylhexyl)-cyclopent-2-en-1-one. SYNTHESIS, 1986(3), 212-213 [10.1055/s-1986-31618].
A Short Route to 2-(6-Methoxycarbonylhexyl)-cyclopent-2-en-1-one
Boga C.;Savoia D.;Trombini C.;Umani-Ronchi A.
1986
Abstract
The prostaglandin intermediate 2-(6-methoxycarbonylhexyl)-cyclopent-2-en-1-one (5) has been prepared by a short synthetic sequence, consisting of the reaction of 2-(1,3-dioxolan-2-yl)-ethylmagnesium bromide (1) with methyl 9-chloro-9-oxononanoate (2), followed by cleavage of the dioxolane ring of 3 and base-induced cyclisation of 4.File in questo prodotto:
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