Anisoles 1, reacting with AlCl3 and PCl3 with appropriate reagent ratios, give, in good yields, the corresponding diaryl methylphosphonates 2 or the methylphoshinates 3b,c and the methylphosphine oxides 4b,c. This unexpected in situ methylphosphorylation explains the reported limited and conflicting results to obtain methoxy-substituted arylphosphonous dichloride with the same reagents. A suggested mechanism is also reported.
Baccolini, G., Boga, C. (1999). New feature of Friedel-Crafts phosphonation of anisoles: Unexpected in situ methylphosphorylation reaction. SYNLETT, 1999(6), 822-824 [10.1055/s-1999-2706].
New feature of Friedel-Crafts phosphonation of anisoles: Unexpected in situ methylphosphorylation reaction
Baccolini G.
;Boga C.
1999
Abstract
Anisoles 1, reacting with AlCl3 and PCl3 with appropriate reagent ratios, give, in good yields, the corresponding diaryl methylphosphonates 2 or the methylphoshinates 3b,c and the methylphosphine oxides 4b,c. This unexpected in situ methylphosphorylation explains the reported limited and conflicting results to obtain methoxy-substituted arylphosphonous dichloride with the same reagents. A suggested mechanism is also reported.File in questo prodotto:
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