The site-selective alkylation of α-aminotropones is effectively realized via gold(I)-catalyzed electrophilic activation of allenamides and allenyl ethers, yielding up to 85% in 30 examples. A dedicated and combined spectroscopic and computational investigation accounts for both chemo- and regioselective profiles of the protocol. New opportunities in the chemical space of tropone/tropolone derivatives are identified.
Gallorini, G., Kiriakidi, S., Bellini, S., Silva López, C., Bertuzzi, G., Bandini, M. (2024). Site-Selective Gold-Catalyzed Alkylation of α‑Aminotropones with Allenes. ORGANIC LETTERS, 24, 9251-9256 [10.1021/acs.orglett.4c03372].
Site-Selective Gold-Catalyzed Alkylation of α‑Aminotropones with Allenes
Giulio Gallorini;Sara Bellini;Giulio Bertuzzi;Marco Bandini
2024
Abstract
The site-selective alkylation of α-aminotropones is effectively realized via gold(I)-catalyzed electrophilic activation of allenamides and allenyl ethers, yielding up to 85% in 30 examples. A dedicated and combined spectroscopic and computational investigation accounts for both chemo- and regioselective profiles of the protocol. New opportunities in the chemical space of tropone/tropolone derivatives are identified.| File | Dimensione | Formato | |
|---|---|---|---|
|
Site-selective (OA).pdf
Open Access dal 21/10/2025
Tipo:
Postprint / Author's Accepted Manuscript (AAM) - versione accettata per la pubblicazione dopo la peer-review
Licenza:
Licenza per accesso libero gratuito
Dimensione
1.27 MB
Formato
Adobe PDF
|
1.27 MB | Adobe PDF | Visualizza/Apri |
|
Site-selective (SI-OA).pdf
accesso aperto
Tipo:
File Supplementare
Licenza:
Licenza per accesso libero gratuito
Dimensione
6.62 MB
Formato
Adobe PDF
|
6.62 MB | Adobe PDF | Visualizza/Apri |
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
