Retrospective, cohort analysis including people with HIV and 4-class drug resistance (4DR). The 8-year probability of malignancy after first evidence of 4DR was 12%, with an incidence of 1.6/100 person years of follow-up. Cancer risk tended to increase with higher precancer viremia copy-years adjusted for time [per 1 - log10 copies/ml higher: adjusted hazard ratio (aHR) = 1.35; 95% confidence interval (95% CI) = 0.98-1.85] and male sex-assigned-at-birth (aHR = 2.50; 95% CI = 0.86-7.27). Efforts to achieve long-term undetectability, risk factor control, prevention, and more aggressive cancer screening are needed in this fragile population.

Clemente, T., Pontillo, D., Malagnino, V., Calza, L., Di Biagio, A., Cenderello, G., et al. (2024). Cancer in people with multidrug-resistant HIV. AIDS, 38(12), 1801-1806 [10.1097/QAD.0000000000003952].

Cancer in people with multidrug-resistant HIV.

Calza L;
2024

Abstract

Retrospective, cohort analysis including people with HIV and 4-class drug resistance (4DR). The 8-year probability of malignancy after first evidence of 4DR was 12%, with an incidence of 1.6/100 person years of follow-up. Cancer risk tended to increase with higher precancer viremia copy-years adjusted for time [per 1 - log10 copies/ml higher: adjusted hazard ratio (aHR) = 1.35; 95% confidence interval (95% CI) = 0.98-1.85] and male sex-assigned-at-birth (aHR = 2.50; 95% CI = 0.86-7.27). Efforts to achieve long-term undetectability, risk factor control, prevention, and more aggressive cancer screening are needed in this fragile population.
2024
Clemente, T., Pontillo, D., Malagnino, V., Calza, L., Di Biagio, A., Cenderello, G., et al. (2024). Cancer in people with multidrug-resistant HIV. AIDS, 38(12), 1801-1806 [10.1097/QAD.0000000000003952].
Clemente, T; Pontillo, D; Malagnino, V; Calza, L; Di Biagio, A; Cenderello, G; Lolatto, R; Manzillo, E; Moioli, Mc; De Socio, Gv; Castagna, A; Spagnuo...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/1001828
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