In this study, we have investigated the nature and magnitude of the immunological response after implantation of human aortic segments. Five recipients of aortic segment replacement were studied for anti-HLA antibody production (specificity and Ig class), CD3, CD4, and CD8 T cell subpopulation dynamics, and aortic wall thickness. Mismatch-specific IgG antibodies to HLA class I and HLA class II antigens were first detected 1-3 months after implantation and persisted in high concentrations for at least 1 year. Computer tomography scanning showed a progressive thickness of the aortic wall. Also the absolute number of CD3, CD4, and CD8 positive lymphocytes increased progressively after implantation. In conclusion, as was observed earlier for heart valve allografts, human implanted aortic segments induce a strong anti-HLA antibody response in recipients. We speculate that these antibodies have the potential to harm the implant, for example, by having an impact on luminal narrowing

Mirelli, M., Nanni-Costa, A., Scolari, M.p., Iannelli, S., Buscaroli, A., Ridolfi, L., et al. (1998). Mismatch-specific anti-HLA antibody production following aorta transplants. TRANSPLANT INTERNATIONAL, 11(0), 444-447 [10.1007/s001470050517].

Mismatch-specific anti-HLA antibody production following aorta transplants

Mirelli M;Scolari MP;Buscaroli A;Stella A;Stefoni S;D'Addato M;Bonomini V
1998

Abstract

In this study, we have investigated the nature and magnitude of the immunological response after implantation of human aortic segments. Five recipients of aortic segment replacement were studied for anti-HLA antibody production (specificity and Ig class), CD3, CD4, and CD8 T cell subpopulation dynamics, and aortic wall thickness. Mismatch-specific IgG antibodies to HLA class I and HLA class II antigens were first detected 1-3 months after implantation and persisted in high concentrations for at least 1 year. Computer tomography scanning showed a progressive thickness of the aortic wall. Also the absolute number of CD3, CD4, and CD8 positive lymphocytes increased progressively after implantation. In conclusion, as was observed earlier for heart valve allografts, human implanted aortic segments induce a strong anti-HLA antibody response in recipients. We speculate that these antibodies have the potential to harm the implant, for example, by having an impact on luminal narrowing
1998
Mirelli, M., Nanni-Costa, A., Scolari, M.p., Iannelli, S., Buscaroli, A., Ridolfi, L., et al. (1998). Mismatch-specific anti-HLA antibody production following aorta transplants. TRANSPLANT INTERNATIONAL, 11(0), 444-447 [10.1007/s001470050517].
Mirelli, M; Nanni-Costa, A; Scolari, Mp; Iannelli, S; Buscaroli, A; Ridolfi, L; Petrini, F; Stella, A; Desanctis, L; Borgnino, Lc; Stefoni, S; D'Addat...espandi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/1000922
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