Out of a total of 736 transplants performed at the Polyclinic of St. Orsola between 1968 and 1994, 149 were from living donor. 92 of these, performed consecutively from 9/77 to 1/95, were selected for the sake of their homogeneity and statistical compatibility. Among these overall graft survival was 82% at 5 yrs and 65% at 10. The main factors affecting graft outcome were: a) HLA compatibility: GS 100% for identical HLA vs 53% for HLA identity ≤ 25%; b) the degree of pre-transplant sensitization: GS 83% in non-hyperimmunized vs 74% in hyperimmunized pts; c) the stimulation index for mixed donor-recipient lymphocyte cultures: GS 87% for index ≤3.5 vs 72% for index >3.5; d) the difference in D-R age: GS 88% for difference ≤10 yrs vs 82% for difference >10 yrs. Best results came from a triple therapy: low- dosed steroids, cyclosporine and azathioprine: GS 100% vs 83% for S+Csa and 78% for S+Aza. GS was not affected by rejection episodes except when these were recurrent: GS 74% Vs 84% and 80% for no, rejection or single-rejection cases, respectively. Surgical and infective complications proved lower than with cadaver transplantation, thanks to the greater planning of the operation, wide-ranging pre-operative clinical and instrumental monitoring and lower pharmacological immunosuppression of the recipient.
Scolari, M.P., Orsi, C., D'Arcangelo, G.L., Buscaroli, A., Stefoni, S., Gregorini, M., et al. (1996). Review of 20 years' clinical experience with living donor kidney transplantation at the Polyclinic of St. Orsola. GIORNALE ITALIANO DI NEFROLOGIA, 13(3), 163-173.
Review of 20 years' clinical experience with living donor kidney transplantation at the Polyclinic of St. Orsola
Scolari M. P.;Orsi C.;Buscaroli A.;Stefoni S.;Gregorini M.;Prandini R.;Bonomini V.;Faenza A.;Cavallari A.;Gozzetti G.
1996
Abstract
Out of a total of 736 transplants performed at the Polyclinic of St. Orsola between 1968 and 1994, 149 were from living donor. 92 of these, performed consecutively from 9/77 to 1/95, were selected for the sake of their homogeneity and statistical compatibility. Among these overall graft survival was 82% at 5 yrs and 65% at 10. The main factors affecting graft outcome were: a) HLA compatibility: GS 100% for identical HLA vs 53% for HLA identity ≤ 25%; b) the degree of pre-transplant sensitization: GS 83% in non-hyperimmunized vs 74% in hyperimmunized pts; c) the stimulation index for mixed donor-recipient lymphocyte cultures: GS 87% for index ≤3.5 vs 72% for index >3.5; d) the difference in D-R age: GS 88% for difference ≤10 yrs vs 82% for difference >10 yrs. Best results came from a triple therapy: low- dosed steroids, cyclosporine and azathioprine: GS 100% vs 83% for S+Csa and 78% for S+Aza. GS was not affected by rejection episodes except when these were recurrent: GS 74% Vs 84% and 80% for no, rejection or single-rejection cases, respectively. Surgical and infective complications proved lower than with cadaver transplantation, thanks to the greater planning of the operation, wide-ranging pre-operative clinical and instrumental monitoring and lower pharmacological immunosuppression of the recipient.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
