This paper reports a 2-year experience of more than 5,000 cross-match tests for renal transplantation. Tests were performed by means of both standard light microscopy and an innovatory method based on flow cytometry, an up-to-date investigative technique for computerized analysis of individual cell characteristics. Flow cytometry allowed a better detection of weak positive reactions (false-negative cross-matches) than light microscopy, thus reducing the risk of selecting candidates with donor presensitization. Transplant clinical outcome supported the value of this original and advanced technological method.
Stefoni, S., Nanni-Costa, A., Buscaroli, A., Borgnino, L.C., Iannelli, S., Raimondi, C., et al. (1991). Validity of flow cytometry for cross-match evaluation in clinical renal transplantation. NEPHRON, 57(3), 268-272 [10.1159/000186274].
Validity of flow cytometry for cross-match evaluation in clinical renal transplantation
Stefoni S.;Buscaroli A.;Raimondi C.;Scolari M. P.;Bonomini V.
1991
Abstract
This paper reports a 2-year experience of more than 5,000 cross-match tests for renal transplantation. Tests were performed by means of both standard light microscopy and an innovatory method based on flow cytometry, an up-to-date investigative technique for computerized analysis of individual cell characteristics. Flow cytometry allowed a better detection of weak positive reactions (false-negative cross-matches) than light microscopy, thus reducing the risk of selecting candidates with donor presensitization. Transplant clinical outcome supported the value of this original and advanced technological method.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
