Organocatalytic Enantioselective Formation of Atropisomers

Asymmetric synthesis of atropisomers is an emerging and challenging field successfully addressed by organocatalysis. The versatility of chiral organic molecules in catalyzing the enantioselective formation of axially chiral compounds is reflected in the enormous number of different classes of atropisomeric structures achievable via a wide range of strategies. This chapter reports an in-depth analysis of covalent and noncovalent organocatalytic methodologies for the synthesis of important axially chiral organic scaffolds, highlighting selected examples of those fundamental strategies that are largely employed in atroposelective synthesis such as desymmetrization, kinetic and dynamic kinetic resolution, alkylation or arylation, cycloaddition, and central-to-axial chirality transfer to name a few.