Vitamin D is increasingly recognized for its role in cardiovascular health beyond its well-established effects on bone metabolism. This review synthesizes findings from observational studies, interventional trials, and meta-analyses to clarify the mechanisms through which vitamin D impacts cardiovascular health, including its influence on vascular function, inflammation, and metabolic pathways. Additionally, this review emphasizes the importance of a personalized approach to vitamin D supplementation, integrating individual cardiovascular risk profiles, baseline vitamin D levels, and comorbid conditions, such as hypertension and diabetes. While current evidence supports the association between low vitamin D levels and increased cardiovascular mortality, this work contributes novel insights by proposing tailored strategies for supplementation, particularly for high-risk subgroups. Practical recommendations for implementing these strategies in clinical practice are also discussed, providing a framework for optimizing cardiovascular outcomes through individualized vitamin D management.
Mattioli, A.V., Coppi, F., Severino, P., Penna, C., Pagliaro, P., Dei Cas, A., et al. (2024). A Personalized Approach to Vitamin D Supplementation in Cardiovascular Health Beyond the Bone: An Expert Consensus by the Italian National Institute for Cardiovascular Research. NUTRIENTS, 17(1), 1-10 [10.3390/nu17010115].
A Personalized Approach to Vitamin D Supplementation in Cardiovascular Health Beyond the Bone: An Expert Consensus by the Italian National Institute for Cardiovascular Research
Mattioli, Anna Vittoria
Primo
Writing – Original Draft Preparation
;Cetrullo, SilviaMembro del Collaboration Group
;Pizzi, CarmineMembro del Collaboration Group
;
2024
Abstract
Vitamin D is increasingly recognized for its role in cardiovascular health beyond its well-established effects on bone metabolism. This review synthesizes findings from observational studies, interventional trials, and meta-analyses to clarify the mechanisms through which vitamin D impacts cardiovascular health, including its influence on vascular function, inflammation, and metabolic pathways. Additionally, this review emphasizes the importance of a personalized approach to vitamin D supplementation, integrating individual cardiovascular risk profiles, baseline vitamin D levels, and comorbid conditions, such as hypertension and diabetes. While current evidence supports the association between low vitamin D levels and increased cardiovascular mortality, this work contributes novel insights by proposing tailored strategies for supplementation, particularly for high-risk subgroups. Practical recommendations for implementing these strategies in clinical practice are also discussed, providing a framework for optimizing cardiovascular outcomes through individualized vitamin D management.File | Dimensione | Formato | |
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nutrients vit D final.pdf
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nutrients-17-00115-s001.zip
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Descrizione: Supplementary Table S1: Observational studies on low levels of vitamin D and cardiovascular disease; Supplementary Table S2: Interventional studies and randomized controlled trials on vitamin D supplementation and cardiovascular outcomes; Supplementary Table S3: Meta-analyses and systematic reviews evaluating the association between low vitamin D levels and an elevated risk of cardiovascular mortality. Author Contributions
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