FIUME, LUIGI
FIUME, LUIGI
DIP. DI PATOLOGIA SPERIMENTALE
A conjugate of doxorubicin with lactosaminated albumin enhances the drug concentrations in all the forms of rat hepatocellular carcinomas independently of their differentation grade.
2006-01-01 Di Stefano G.; Fiume L.; Baglioni M.; Bolondi L.; Busi C.; Chieco P.; Kratz F.; Manaresi F.; Pariali M.
A novel method for coupling doxorubicin to lactosaminated human albumin by an acid sensitive hydrazone bond: synthesis, characterization and preliminary biological properties of the conjugate.
2004-01-01 DI STEFANO G.; LANZA M.; KRATZ F.; MERINA L.; FIUME L.
Albumin-drug conjugates in the treatment of hepatic disorders.
2014-01-01 Fiume L;Manerba M;Di Stefano G
Binding of the doxorubicin-lactosaminated human albumin conjugate to HCC cells is mediated by the drug moieties.
2008-01-01 Baglioni M.; Fiume L.; Bolondi L.; Farina C.; Kratz F.; Di Stefano G.
Characterisation of the conjugate of the (6-maleimidocaproyl)hydrazone derivative of doxorubicin with lactosaminated human albumin by 13C NMR spectroscopy.
2009-01-01 Boga C.; Fiume L.; Baglioni M.; Bertucci C.; Farina C.; Kratz F.; Manerba M.; Naldi M.; Di Stefano G.
Coupling of lactose molecules to the carrier protein hinders the spleen and bone marrow uptake of doxorubicin conjugated with human albumin
2007-01-01 Di Stefano G; Fiume L; Baglioni M; Busi C; Chieco P; Kratz F; Mattioli A.
Doxorubicin coupled to lactosaminated albumin inhibits the growth of hepatocellular carcinomas induced in rats by diethylnitrosamine.
2005-01-01 FIUME L.; BOLONDI L.; BUSI C.; CHIECO P.; KRATZ F.; LANZA M.; MATTIOLI A.; DI STEFANO G.
Doxorubicin coupled to lactosaminated albumin: effect of heterogeneity in drug load on conjugate disposition and hepatocellular carcinoma uptake in rats.
2008-01-01 Di Stefano G.; Fiume L.; Baglioni M.; Busi C.; Bolondi L.; Farina C.; Mori F.; Chieco P.; Pariali M.; Kratz F.; Molin L.; Salmaso S.; Caliceti P.
Doxorubicin coupled to lactosaminated albumin: effects on rats with liver fibrosis and cirrhosis.
2006-01-01 Di Stefano G; Fiume L; Domenicali M; Busi C; Chieco P; Kratz F; Lanza M; Mattioli A; Pariali M; Bernardi M.
Doxorubicin coupled to lactosaminated albumin: enhanced drug levels in rat hepatocarcinomas.
2006-01-01 Di Stefano G.; Busi C.; Chieco P.; Pariali M.; Fiume L.
Doxorubicin coupled to lactosaminated human albumin: a hepatocellular carcinoma targeted drug.
2008-01-01 Fiume L.; Baglioni M.; Bolondi L.; Farina C.; Di Stefano G.
Effect of sorafenib on the energy metabolism of hepatocellular carcinoma cells.
2011-01-01 Fiume L.; Manerba M.; Vettraino M.; Di Stefano G.
Efficacy of doxorubicin coupled to lactosaminated albumin on rat hepatocellular carcinomas evaluated by ultrasound imaging.
2008-01-01 Di Stefano G.; Fiume L.; Baglioni M.; Bolondi L.; Chieco P.; Kratz F.; Pariali M.; Rubini G.
Enhanced uptake of lactosaminated human albumin by rat hepatocarcinomas: implications for an improved chemotherapy of primary liver tumors.
2005-01-01 DI STEFANO G.; FIUME L.; BOLONDI L.; LANZA M.; PARIALI M.; CHIECO P.
Galloflavin (CAS 568-80-9), a novel inhibitor of lactate dehydrogenase.
2012-01-01 Manerba M.; Vettraino M.; Fiume L.; Di Stefano G.; Sartini A.; Giacomini E.; Buonfiglio R.; Roberti M.; Recanatini M.
Galloflavin prevents the binding of lactate dehydrogenase A to single stranded DNA and inhibits RNA synthesis in cultured cells.
2013-01-01 Fiume L.; Vettraino M.; Carnicelli D.; Arfilli V.; Di Stefano G.; Brigotti M.
Galloflavin, a new lactate dehydrogenase inhibitor, induces the death of human breast cancer cells with different glycolytic attitude by affecting distinct signaling pathways.
2012-01-01 Farabegoli F.; Vettraino M.; Manerba M.; Fiume L.; Roberti M.; Di Stefano G.
Impairment of aerobic glycolysis by inhibitors of lactic dehydrogenase hinders the growth of human hepatocellular carcinoma cell lines.
2010-01-01 Fiume L; Manerba M; Vettraino M; Di Stefano G
The inhibition of lactate dehydrogenase A hinders the transcription of histone 2B gene independently from the block of aerobic glycolysis
2017-01-01 Brighenti, Elisa; Carnicelli, Domenica; Brigotti, Maurizio; Fiume, Luigi
Inhibition of lactate dehydrogenase activity as an approach to cancer therapy
2014-01-01 Luigi FIUME; Marcella MANERBA; Marina VETTRAINO; Giuseppina DI STEFANO