SANTUCCI, MARIA ALESSANDRA
SANTUCCI, MARIA ALESSANDRA
DIPARTIMENTO DI MEDICINA SPECIALISTICA, DIAGNOSTICA E SPERIMENTALE (attivo dal 28/10/2011 al 31/12/2022)
Ponatinib treatment in chronic myeloid leukemia cell lines targets aurora kinase A/FOXM1 axis
2020 Mancini, Manuela; De Santis, Sara; Monaldi, Cecilia; Bavaro, Luana; Martelli, Margherita; Gugliotta, Gabriele; Castagnetti, Fausto; Rosti, Gianantonio; Santucci, Maria Alessandra; Martinelli, Giovanni; Cavo, Michele; Soverini, Simona
Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors
2019 Mancini M.; De Santis S.; Monaldi C.; Bavaro L.; Martelli M.; Castagnetti F.; Gugliotta G.; Rosti G.; Santucci M.A.; Martinelli G.; Cavo M.; Soverini S.
Chibby 1: A new component of β-catenin-signaling in chronic myeloid leukemia
2017 Mancini, Manuela; Soverini, Simona; Gugliotta, Gabriele; Santucci, MARIA ALESSANDRA; Rosti, Gianantonio; Cavo, Michele; Martinelli, Giovanni; Castagnetti, Fausto
FOXM1 Transcription Factor: A New Component of Chronic Myeloid Leukemia Stem Cell Proliferation Advantage
2017 Mancini, Manuela; Castagnetti, Fausto; Soverini, Simona; Leo, Elisa; De Benedittis, Caterina; Gugliotta, Gabriele; Rosti, Gianantonio; Bavaro, Luana; De Santis, Sara; Monaldi, Cecilia; Martelli, Margherita; Santucci, Maria Alessandra; Cavo, Michele; Martinelli, Giovanni
14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia
2015 Mancini, Manuela; Leo, Elisa; Takemaru, Ken-Ichi; Campi, Virginia; Castagnetti, Fausto; Soverini, Simona; De Benedittis, Caterina; Rosti, Gianantonio; Cavo, Michele; Santucci, Maria Alessandra; Martinelli, Giovanni
DNA methyltransferase 1 drives transcriptional down-modulation of β catenin antagonist Chibby1 associated with the BCR-ABL1 gene of chronic myeloid leukemia.
2015 Leo, E; Mancini, M; Castagnetti, F; Gugliotta, G; Santucci, Ma; Martinelli, G.
A calpain-cleaved fragment of β-catenin promotes BCRABL1+ cell survival evoked by autophagy induction in response to imatinib
2014 Mancini, Manuela; Leo, Elisa; Campi, Virginia; Castagnetti, Fausto; Zazzeroni, Luca; Gugliotta, Gabriele; Santucci, MARIA ALESSANDRA; Martinelli, Giovanni
FOXM1 Transcription Factor Is a Component of Beta Catenin Signaling in Hematopoietic Progenitors of Chronic Myeloid Leukemia
2014 Leo, Elisa; Simonetti, Giorgia; Mancini, Manuela; Veljkovic, Nevena; Campi, Virginia; Castagnetti, Fausto; Gugliotta, Gabriele; DE BENEDITTIS, Caterina; Santucci, MARIA ALESSANDRA; Martinelli, Giovanni
BCR-ABL1-associated reduction of beta catenin antagonist Chibby1 in chronic myeloid leukemia.
2013 Leo E;Mancini M;Aluigi M;Luatti S;Castagnetti F;Testoni N;Soverini S;Santucci MA;Martinelli G
Chibby drives β catenin cytoplasmic accumulation leading to activation of the unfolded protein response in BCR-ABL1+ cells
2013 Manuela Mancini;Elisa Leo;Ken-Ichi Takemaru;Virginia Campi;Enrica Borsi;Fausto Castagnetti;Gabriele Gugliotta;Maria Alessandra Santucci;Giovanni Martinelli
Cytoplasmatic compartmentalization by Bcr-Abl promotes TET2 loss-of-function in chronic myeloid leukemia
2012 Manuela Mancini;Nevena Veljkovic;Elisa Leo;Michela Aluigi;Enrica Borsi;Chiara Galloni;Ilaria Iacobucci;Enza Barbieri;Maria Alessandra Santucci
Gadd45a transcriptional induction elicited by the Aurora kinase inhibitor MK-0457 in Bcr-Abl-expressing cells is driven by Oct-1 transcription factor
2012 Manuela Mancini;Elisa Leo;Michela Aluigi;Chiara Marcozzi;Enrica Borsi;Enza Barbieri;Maria Alessandra Santucci
HIF-1a INHIBITION PROMOTES CELL CYCLE ARREST IN MULTIPLE MYELOMA
2012 G Perrone; E Borsi; C Terragna; M Martello; M Mancini; M Aluigi; MA Santucci; G Martinelli; M Baccarani; M Cavo
Histone H3 covalent modifications driving response of BCR-ABL1+ cells sensitive and resistant to imatinib to Aurora kinase inhibitor MK-0457
2012 Mancini M.; Aluigi M.; Leo E.; Marcozzi C.; Castagnetti F.; Barbieri E.; Santucci MA.
We are very happy and proud of this monographic issue of the Giornale Italiano di Dermatologia e Venereologia. Introduction.
2012 Bernengo MG;Santucci M;Zinzani PL
HIF 1 Alpha: A Suitable Target for Multiple Myeloma
2011 PERRONE G; BORSI E; TERRAGNA C; DURANTE S; MARTELLO M; ALUIGI M; MANCINI M; ZAMAGNI E; TACCHETTI P; BRIOLI A; PANTANI L; ZANNETTI BA; MARTINELLI G; SANTUCCI MA; BACCARANI M; CAVO M
Idetification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein-protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis.
2010 Corradi V.; Mancini M.; Manetti F.; Petta S.; Santucci M.A.; Botta M.
mTOR inhibitor RAD001 (Everloimus) enhances the effects of imatinib in chronic myeloid leukemia by raising the nuclear expression of c-Abl protein
2010 M. Mancini; V. Corradi; S. Petta; G. Martinelli; E. Barbieri; M.A. Santucci
New SRC/ABL inhibitors for chronic myeloid leukemia therapy show selectivity for T315I ABL mutant CD34(+) cells
2010 Santucci MA; Mancini M; Corradi V; Iacobucci I; Martinelli G; Botta M; Schenone S
RAD001 (everolimus) prevents mTOR and Akt late re-activation in response to imatinib in chronic myeloid leukemia
2010 M. Mancini; S. Petta; G. Martinelli; E. Barbieri; M.A. Santucci
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| Ponatinib treatment in chronic myeloid leukemia cell lines targets aurora kinase A/FOXM1 axis | Mancini, Manuela; De Santis, Sara; Monaldi, Cecilia; Bavaro, Luana; Martelli, Margherita; Gugliot...ta, Gabriele; Castagnetti, Fausto; Rosti, Gianantonio; Santucci, Maria Alessandra; Martinelli, Giovanni; Cavo, Michele; Soverini, Simona | 2020-01-01 | HEMATOLOGICAL ONCOLOGY | - | 1.01 Articolo in rivista | - |
| Hyper-activation of Aurora kinase a-polo-like kinase 1-FOXM1 axis promotes chronic myeloid leukemia resistance to tyrosine kinase inhibitors | Mancini M.; De Santis S.; Monaldi C.; Bavaro L.; Martelli M.; Castagnetti F.; Gugliotta G.; Rosti... G.; Santucci M.A.; Martinelli G.; Cavo M.; Soverini S. | 2019-01-01 | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | - | 1.01 Articolo in rivista | Mancini_J Exp Clin Cancer Res_2019.pdf |
| Chibby 1: A new component of β-catenin-signaling in chronic myeloid leukemia | Mancini, Manuela; Soverini, Simona; Gugliotta, Gabriele; Santucci, MARIA ALESSANDRA; Rosti, Giana...ntonio; Cavo, Michele; Martinelli, Giovanni; Castagnetti, Fausto | 2017-01-01 | ONCOTARGET | - | 1.01 Articolo in rivista | - |
| FOXM1 Transcription Factor: A New Component of Chronic Myeloid Leukemia Stem Cell Proliferation Advantage | Mancini, Manuela; Castagnetti, Fausto; Soverini, Simona; Leo, Elisa; De Benedittis, Caterina; Gug...liotta, Gabriele; Rosti, Gianantonio; Bavaro, Luana; De Santis, Sara; Monaldi, Cecilia; Martelli, Margherita; Santucci, Maria Alessandra; Cavo, Michele; Martinelli, Giovanni | 2017-01-01 | JOURNAL OF CELLULAR BIOCHEMISTRY | - | 1.01 Articolo in rivista | - |
| 14-3-3 Binding and Sumoylation Concur to the Down-Modulation of β-catenin Antagonist chibby 1 in Chronic Myeloid Leukemia | Mancini, Manuela; Leo, Elisa; Takemaru, Ken-Ichi; Campi, Virginia; Castagnetti, Fausto; Soverini,... Simona; De Benedittis, Caterina; Rosti, Gianantonio; Cavo, Michele; Santucci, Maria Alessandra; Martinelli, Giovanni | 2015-01-01 | PLOS ONE | - | 1.01 Articolo in rivista | Mancini_PONE_2015.pdf; pone.0131074.s001.pdf; pone.0131074.s002.pdf; pone.0131074.s003.pdf; pone.0131074.s004.pdf; pone.0131074.s004.pdf |
| DNA methyltransferase 1 drives transcriptional down-modulation of β catenin antagonist Chibby1 associated with the BCR-ABL1 gene of chronic myeloid leukemia. | Leo, E; Mancini, M; Castagnetti, F; Gugliotta, G; Santucci, Ma; Martinelli, G. | 2015-01-01 | JOURNAL OF CELLULAR BIOCHEMISTRY | - | 1.01 Articolo in rivista | - |
| A calpain-cleaved fragment of β-catenin promotes BCRABL1+ cell survival evoked by autophagy induction in response to imatinib | Mancini, Manuela; Leo, Elisa; Campi, Virginia; Castagnetti, Fausto; Zazzeroni, Luca; Gugliotta, G...abriele; Santucci, MARIA ALESSANDRA; Martinelli, Giovanni | 2014-01-01 | CELLULAR SIGNALLING | - | 1.01 Articolo in rivista | - |
| FOXM1 Transcription Factor Is a Component of Beta Catenin Signaling in Hematopoietic Progenitors of Chronic Myeloid Leukemia | Leo, Elisa; Simonetti, Giorgia; Mancini, Manuela; Veljkovic, Nevena; Campi, Virginia; Castagnetti..., Fausto; Gugliotta, Gabriele; DE BENEDITTIS, Caterina; Santucci, MARIA ALESSANDRA; Martinelli, Giovanni | 2014-01-01 | BLOOD | - | 1.06 Abstract in rivista | - |
| BCR-ABL1-associated reduction of beta catenin antagonist Chibby1 in chronic myeloid leukemia. | Leo E;Mancini M;Aluigi M;Luatti S;Castagnetti F;Testoni N;Soverini S;Santucci MA;Martinelli G | 2013-01-01 | PLOS ONE | - | 1.01 Articolo in rivista | Leo et al_PONE2013.pdf |
| Chibby drives β catenin cytoplasmic accumulation leading to activation of the unfolded protein response in BCR-ABL1+ cells | Manuela Mancini;Elisa Leo;Ken-Ichi Takemaru;Virginia Campi;Enrica Borsi;Fausto Castagnetti;Gabrie...le Gugliotta;Maria Alessandra Santucci;Giovanni Martinelli | 2013-01-01 | CELLULAR SIGNALLING | - | 1.01 Articolo in rivista | - |
| Cytoplasmatic compartmentalization by Bcr-Abl promotes TET2 loss-of-function in chronic myeloid leukemia | Manuela Mancini;Nevena Veljkovic;Elisa Leo;Michela Aluigi;Enrica Borsi;Chiara Galloni;Ilaria Iaco...bucci;Enza Barbieri;Maria Alessandra Santucci | 2012-01-01 | JOURNAL OF CELLULAR BIOCHEMISTRY | - | 1.01 Articolo in rivista | - |
| Gadd45a transcriptional induction elicited by the Aurora kinase inhibitor MK-0457 in Bcr-Abl-expressing cells is driven by Oct-1 transcription factor | Manuela Mancini;Elisa Leo;Michela Aluigi;Chiara Marcozzi;Enrica Borsi;Enza Barbieri;Maria Alessan...dra Santucci | 2012-01-01 | LEUKEMIA RESEARCH | - | 1.01 Articolo in rivista | - |
| HIF-1a INHIBITION PROMOTES CELL CYCLE ARREST IN MULTIPLE MYELOMA | G Perrone; E Borsi; C Terragna; M Martello; M Mancini; M Aluigi; MA Santucci; G Martinelli; M Bac...carani; M Cavo | 2012-01-01 | HAEMATOLOGICA | - | 4.02 Riassunto (Abstract) | - |
| Histone H3 covalent modifications driving response of BCR-ABL1+ cells sensitive and resistant to imatinib to Aurora kinase inhibitor MK-0457 | Mancini M.; Aluigi M.; Leo E.; Marcozzi C.; Castagnetti F.; Barbieri E.; Santucci MA. | 2012-01-01 | BRITISH JOURNAL OF HAEMATOLOGY | - | 1.01 Articolo in rivista | - |
| We are very happy and proud of this monographic issue of the Giornale Italiano di Dermatologia e Venereologia. Introduction. | Bernengo MG;Santucci M;Zinzani PL | 2012-01-01 | GIORNALE ITALIANO DI DERMATOLOGIA E VENEREOLOGIA | - | 1.04 Replica / breve intervento (e simili) | - |
| HIF 1 Alpha: A Suitable Target for Multiple Myeloma | PERRONE G; BORSI E; TERRAGNA C; DURANTE S; MARTELLO M; ALUIGI M; MANCINI M; ZAMAGNI E; TACCHETTI ...P; BRIOLI A; PANTANI L; ZANNETTI BA; MARTINELLI G; SANTUCCI MA; BACCARANI M; CAVO M | 2011-01-01 | BLOOD | - | 4.02 Riassunto (Abstract) | - |
| Idetification of the first non-peptidic small molecule inhibitor of the c-Abl/14-3-3 protein-protein interactions able to drive sensitive and Imatinib-resistant leukemia cells to apoptosis. | Corradi V.; Mancini M.; Manetti F.; Petta S.; Santucci M.A.; Botta M. | 2010-01-01 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - | 1.01 Articolo in rivista | - |
| mTOR inhibitor RAD001 (Everloimus) enhances the effects of imatinib in chronic myeloid leukemia by raising the nuclear expression of c-Abl protein | M. Mancini; V. Corradi; S. Petta; G. Martinelli; E. Barbieri; M.A. Santucci | 2010-01-01 | LEUKEMIA RESEARCH | - | 1.01 Articolo in rivista | - |
| New SRC/ABL inhibitors for chronic myeloid leukemia therapy show selectivity for T315I ABL mutant CD34(+) cells | Santucci MA; Mancini M; Corradi V; Iacobucci I; Martinelli G; Botta M; Schenone S | 2010-01-01 | INVESTIGATIONAL NEW DRUGS | - | 1.01 Articolo in rivista | - |
| RAD001 (everolimus) prevents mTOR and Akt late re-activation in response to imatinib in chronic myeloid leukemia | M. Mancini; S. Petta; G. Martinelli; E. Barbieri; M.A. Santucci | 2010-01-01 | JOURNAL OF CELLULAR BIOCHEMISTRY | - | 1.01 Articolo in rivista | - |