FUCHS, CLAUDIA
FUCHS, CLAUDIA
DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE
Age-related cognitive and motor decline in a mouse model of CDKL5 deficiency disorder is associated with increased neuronal senescence and death
2021-01-01 Gennaccaro L.; Fuchs C.; Loi M.; Pizzo R.; Alvente S.; Berteotti C.; Lupori L.; Sagona G.; Galvani G.; Gurgone A.; Raspanti A.; Medici G.; Tassinari M.; Trazzi S.; Ren E.; Rimondini R.; Pizzorusso T.; Zoccoli G.; Giustetto M.; Ciani E.
APP-dependent alteration of GSK3β activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome.
2014-01-01 Trazzi S;Fuchs C;De Franceschi M;Mitrugno VM;Bartesaghi R;Ciani E
APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome.
2011-01-01 Trazzi S.; Mitrugno V.M.; Valli E.; Fuchs C.; Rizzi S.; Guidi S.; Perini G.; Bartesaghi R.; Ciani E.
CDKL5 deficiency predisposes neurons to cell death through the deregulation of SMAD3 signaling (vol 29, pg 658, 2019)
2019-01-01 Fuchs C.; Medici G.; Trazzi S.; Gennaccaro L.; Galvani G.; Berteotti C.; Ren E.; Loi M.; Ciani E.
CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder
2018-01-01 Trazzi, Stefania; De Franceschi, Marianna; Fuchs, Claudia; Bastianini, Stefano; Viggiano, Rocchina; Lupori, Leonardo; Mazziotti, Raffaele; Medici, Giorgio; Martire, Viviana Lo; Ren, Elisa; Rimondini, Roberto; Zoccoli, Giovanna; Bartesaghi, Renata; Pizzorusso, Tommaso; Ciani, Elisabetta*
CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells
2012-01-01 VALLI E; TRAZZI S; FUCHS C; ERRIQUEZ D; BARTESAGHI R; PERINI G; CIANI E
Early-occurring proliferation defects in peripheral tissues of the Ts65Dn mouse model of Down syndrome are associated with patched1 over expression
2012-01-01 Fuchs C; Ciani E; Guidi S; Trazzi S; Bartesaghi R
Functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder are rescued by a TrkB agonist
2019-01-01 Ren E.; Roncace V.; Trazzi S.; Fuchs C.; Medici G.; Gennaccaro L.; Loi M.; Galvani G.; Ye K.; Rimondini R.; Aicardi G.; Ciani E.
Functional impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder are ameliorated by a GABAB receptor antagonist
2020-01-01 Anna Cecilia Berardi, Claudia Fuchs, Laura Gennaccaro, Vincenzo Roncacè, Yassine Aitbali, Elisa Ren, Stefania Trazzi, Maurizio Giustetto, Giorgio Aicardi, Elisabetta Ciani
A GABAB receptor antagonist rescues functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder
2021-01-01 Laura Gennaccaro, Claudia Fuchs, Manuela Loi, Vincenzo Roncacè, Stefania Trazzi, Yassine Ait-Bali, Giuseppe Galvani, Anna Cecilia Berardi, Giorgio Medici, Marianna Tassinari, Elisa Ren, Roberto Rimondini, Maurizio Giustetto, Giorgio Aicardi, Elisabetta Ciani
The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo
2020-01-01 Trovo L.; Fuchs C.; De Rosa R.; Barbiero I.; Tramarin M.; Ciani E.; Rusconi L.; Kilstrup-Nielsen C.
HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder
2016-01-01 Trazzi, Stefania; Fuchs, Claudia; Viggiano, Rocchina; De Franceschi, Marianna; Valli, Emanuele; Jedynak, Paulina; Hansen, Finn K; Perini, Giovanni; Rimondini, Roberto; Kurz, Thomas; Bartesaghi, Renata; Ciani, Elisabetta
Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder
2018-01-01 Fuchs, Claudia; Gennaccaro, Laura; Trazzi, Stefania; Bastianini, Stefano; Bettini, Simone; Martire, Viviana Lo; Ren, Elisa; Medici, Giorgio; Zoccoli, Giovanna; Rimondini, Roberto; Ciani, Elisabetta*
Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons
2020-01-01 Loi M.; Trazzi S.; Fuchs C.; Galvani G.; Medici G.; Gennaccaro L.; Tassinari M.; Ciani E.
Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder
2015-01-01 Fuchs, C.; Rimondini, R.; Viggiano, R.; Trazzi, S.; De Franceschi, M.; Bartesaghi, R.; Ciani, E.
Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder
2021-01-01 Galvani, Giuseppe; Mottolese, Nicola; Gennaccaro, Laura; Loi, Manuela; Medici, Giorgio; Tassinari, Marianna; Fuchs, Claudia; Ciani, Elisabetta; Trazzi, Stefania
Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling.
2014-01-01 Fuchs C;Trazzi S;Torricella R;Viggiano R;De Franceschi M;Amendola E;Gross C;Calzà L;Bartesaghi R;Ciani E
Mapping pathological phenotypes in a mouse model of CDKL5 disorder.
2014-01-01 Amendola E;Zhan Y;Mattucci C;Castroflorio E;Calcagno E;Fuchs C;Lonetti G;Silingardi D;Vyssotski AL;Farley D;Ciani E;Pizzorusso T;Giustetto M;Gross CT
Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder
2020-01-01 Fuchs C.; Gennaccaro L.; Ren E.; Galvani G.; Trazzi S.; Medici G.; Loi M.; Conway E.; Devinsky O.; Rimondini R.; Ciani E.
Site-specific abnormalities in the visual system of a mouse model of CDKL5 deficiency disorder
2019-01-01 Lupori L.; Sagona G.; Fuchs C.; Mazziotti R.; Stefanov A.; Putignano E.; Napoli D.; Strettoi E.; Ciani E.; Pizzorusso T.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| Age-related cognitive and motor decline in a mouse model of CDKL5 deficiency disorder is associated with increased neuronal senescence and death | Gennaccaro L.; Fuchs C.; Loi M.; Pizzo R.; Alvente S.; Berteotti C.; Lupori L.; Sagona G.; Galvani G.; Gurgone A.; Raspanti A.; Medici G.; Tassinari M.; Trazzi S.; Ren E.; Rimondini R.; Pizzorusso T.; Zoccoli G.; Giustetto M.; Ciani E. | 2021-01-01 | AGING AND DISEASE | - | 1.01 Articolo in rivista | Gennaccaro et al 2021Age.pdf |
| APP-dependent alteration of GSK3β activity impairs neurogenesis in the Ts65Dn mouse model of Down syndrome. | Trazzi S;Fuchs C;De Franceschi M;Mitrugno VM;Bartesaghi R;Ciani E | 2014-01-01 | NEUROBIOLOGY OF DISEASE | - | 1.01 Articolo in rivista | - |
| APP-dependent up-regulation of Ptch1 underlies proliferation impairment of neural precursors in Down syndrome. | Trazzi S.; Mitrugno V.M.; Valli E.; Fuchs C.; Rizzi S.; Guidi S.; Perini G.; Bartesaghi R.; Ciani E. | 2011-01-01 | HUMAN MOLECULAR GENETICS | - | 1.01 Articolo in rivista | - |
| CDKL5 deficiency predisposes neurons to cell death through the deregulation of SMAD3 signaling (vol 29, pg 658, 2019) | Fuchs C.; Medici G.; Trazzi S.; Gennaccaro L.; Galvani G.; Berteotti C.; Ren E.; Loi M.; Ciani E. | 2019-01-01 | BRAIN PATHOLOGY | - | 1.01 Articolo in rivista | - |
| CDKL5 protein substitution therapy rescues neurological phenotypes of a mouse model of CDKL5 disorder | Trazzi, Stefania; De Franceschi, Marianna; Fuchs, Claudia; Bastianini, Stefano; Viggiano, Rocchina; Lupori, Leonardo; Mazziotti, Raffaele; Medici, Giorgio; Martire, Viviana Lo; Ren, Elisa; Rimondini, Roberto; Zoccoli, Giovanna; Bartesaghi, Renata; Pizzorusso, Tommaso; Ciani, Elisabetta* | 2018-01-01 | HUMAN MOLECULAR GENETICS | - | 1.01 Articolo in rivista | trazzi2018 .pdf |
| CDKL5, a novel MYCN-repressed gene, blocks cell cycle and promotes differentiation of neuronal cells | VALLI E; TRAZZI S; FUCHS C; ERRIQUEZ D; BARTESAGHI R; PERINI G; CIANI E | 2012-01-01 | BIOCHIMICA ET BIOPHYSICA ACTA. GENE REGULATORY MECHANISMS | - | 1.01 Articolo in rivista | - |
| Early-occurring proliferation defects in peripheral tissues of the Ts65Dn mouse model of Down syndrome are associated with patched1 over expression | Fuchs C; Ciani E; Guidi S; Trazzi S; Bartesaghi R | 2012-01-01 | LABORATORY INVESTIGATION | - | 1.01 Articolo in rivista | - |
| Functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder are rescued by a TrkB agonist | Ren E.; Roncace V.; Trazzi S.; Fuchs C.; Medici G.; Gennaccaro L.; Loi M.; Galvani G.; Ye K.; Rimondini R.; Aicardi G.; Ciani E. | 2019-01-01 | FRONTIERS IN CELLULAR NEUROSCIENCE | - | 1.01 Articolo in rivista | fncel-13-00169.pdf |
| Functional impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder are ameliorated by a GABAB receptor antagonist | Anna Cecilia Berardi, Claudia Fuchs, Laura Gennaccaro, Vincenzo Roncacè, Yassine Aitbali, Elisa Ren, Stefania Trazzi, Maurizio Giustetto, Giorgio Aicardi, Elisabetta Ciani | 2020-01-01 | - | - | 4.03 Poster | - |
| A GABAB receptor antagonist rescues functional and structural impairments in the perirhinal cortex of a mouse model of CDKL5 deficiency disorder | Laura Gennaccaro, Claudia Fuchs, Manuela Loi, Vincenzo Roncacè, Stefania Trazzi, Yassine Ait-Bali, Giuseppe Galvani, Anna Cecilia Berardi, Giorgio Medici, Marianna Tassinari, Elisa Ren, Roberto Rimondini, Maurizio Giustetto, Giorgio Aicardi, Elisabetta Ciani | 2021-01-01 | NEUROBIOLOGY OF DISEASE | - | 1.01 Articolo in rivista | Gennaccaro et al 2021GABA.pdf; Supplementary data.docx |
| The green tea polyphenol epigallocatechin-3-gallate (EGCG) restores CDKL5-dependent synaptic defects in vitro and in vivo | Trovo L.; Fuchs C.; De Rosa R.; Barbiero I.; Tramarin M.; Ciani E.; Rusconi L.; Kilstrup-Nielsen C. | 2020-01-01 | NEUROBIOLOGY OF DISEASE | - | 1.01 Articolo in rivista | - |
| HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder | Trazzi, Stefania; Fuchs, Claudia; Viggiano, Rocchina; De Franceschi, Marianna; Valli, Emanuele; Jedynak, Paulina; Hansen, Finn K; Perini, Giovanni; Rimondini, Roberto; Kurz, Thomas; Bartesaghi, Renata; Ciani, Elisabetta | 2016-01-01 | HUMAN MOLECULAR GENETICS | - | 1.01 Articolo in rivista | - |
| Heterozygous CDKL5 Knockout Female Mice Are a Valuable Animal Model for CDKL5 Disorder | Fuchs, Claudia; Gennaccaro, Laura; Trazzi, Stefania; Bastianini, Stefano; Bettini, Simone; Martire, Viviana Lo; Ren, Elisa; Medici, Giorgio; Zoccoli, Giovanna; Rimondini, Roberto; Ciani, Elisabetta* | 2018-01-01 | NEURAL PLASTICITY | - | 1.01 Articolo in rivista | 9726950(1).pdf; Supplementary Materials.zip |
| Increased DNA Damage and Apoptosis in CDKL5-Deficient Neurons | Loi M.; Trazzi S.; Fuchs C.; Galvani G.; Medici G.; Gennaccaro L.; Tassinari M.; Ciani E. | 2020-01-01 | MOLECULAR NEUROBIOLOGY | - | 1.01 Articolo in rivista | - |
| Inhibition of GSK3β rescues hippocampal development and learning in a mouse model of CDKL5 disorder | Fuchs, C.; Rimondini, R.; Viggiano, R.; Trazzi, S.; De Franceschi, M.; Bartesaghi, R.; Ciani, E. | 2015-01-01 | NEUROBIOLOGY OF DISEASE | - | 1.01 Articolo in rivista | - |
| Inhibition of microglia overactivation restores neuronal survival in a mouse model of CDKL5 deficiency disorder | Galvani, Giuseppe; Mottolese, Nicola; Gennaccaro, Laura; Loi, Manuela; Medici, Giorgio; Tassinari, Marianna; Fuchs, Claudia; Ciani, Elisabetta; Trazzi, Stefania | 2021-01-01 | JOURNAL OF NEUROINFLAMMATION | - | 1.01 Articolo in rivista | Galvani et al 2021.pdf |
| Loss of CDKL5 impairs survival and dendritic growth of newborn neurons by altering AKT/GSK-3β signaling. | Fuchs C;Trazzi S;Torricella R;Viggiano R;De Franceschi M;Amendola E;Gross C;Calzà L;Bartesaghi R;Ciani E | 2014-01-01 | NEUROBIOLOGY OF DISEASE | - | 1.01 Articolo in rivista | - |
| Mapping pathological phenotypes in a mouse model of CDKL5 disorder. | Amendola E;Zhan Y;Mattucci C;Castroflorio E;Calcagno E;Fuchs C;Lonetti G;Silingardi D;Vyssotski AL;Farley D;Ciani E;Pizzorusso T;Giustetto M;Gross CT | 2014-01-01 | PLOS ONE | - | 1.01 Articolo in rivista | 10.1371_journal.pone.0091613.PDF |
| Pharmacotherapy with sertraline rescues brain development and behavior in a mouse model of CDKL5 deficiency disorder | Fuchs C.; Gennaccaro L.; Ren E.; Galvani G.; Trazzi S.; Medici G.; Loi M.; Conway E.; Devinsky O.; Rimondini R.; Ciani E. | 2020-01-01 | NEUROPHARMACOLOGY | - | 1.01 Articolo in rivista | - |
| Site-specific abnormalities in the visual system of a mouse model of CDKL5 deficiency disorder | Lupori L.; Sagona G.; Fuchs C.; Mazziotti R.; Stefanov A.; Putignano E.; Napoli D.; Strettoi E.; Ciani E.; Pizzorusso T. | 2019-01-01 | HUMAN MOLECULAR GENETICS | - | 1.01 Articolo in rivista | ddz102.pdf; supplementary_material_ddz102.pdf |