SIMONI, ELENA
SIMONI, ELENA
DIPARTIMENTO DI FARMACIA E BIOTECNOLOGIE
Assegnisti
An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512
2015 Palermo, G.; Minniti, E.; Greco, M.L.; Riccardi, L.; Simoni, E.; Convertino, M.; Marchetti, C.; Rosini, M.; Sissi, C.; Minarini, A.; De Vivo, M.
Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.
2016 Tarozzi, A; Marchetti, C; Nicolini, B; D'Amico, M; Ticchi, N; Pruccoli, L; Tumiatti, V; Simoni, E; Lodola, A; Mor, M; Milelli, A; Minarini, A.
Combining galantamine and memantine in dual-target new chemical entities for the treatment of Alzheimer’s disease
2012 Simoni E.; Daniele S.; Bottegoni G.; Pizzirani D.; Tarozzo G.; Reggiani A.; Trincavelli M.L.; Martini C.; Piomelli D.; Melchiorre C.; Rosini M.; Cavalli A.
Curcumin analogs as multi-target antioxidants: focus on mitochondria.
2010 E. Simoni; M. Rosini; C. Bergamini; R. Fato; M.L. Bolognesi; A. Cavalli; R. Motterlini; G. Lenaz; C. Melchiorre
Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment.
2012 Minarini A.; Milelli A.; Tumiatti V.; Rosini M.; Simoni E.; Bolognesi M.L.; Andrisano V.; Bartolini M.; Motori E.; Angeloni C.; Hrelia S.
Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment
2011 A. Minarini; A. Milelli; V. Tumiatti; E. Simoni; M. L. Bolognesi; V. Andrisano; M. Bartolini; E. Motori; C. Angeloni ; S. Hrelia; C.Melchiorre
Design, Synthesis, and biological evaluation of naphtalene diimides derivatives as anticancer agent
2010 A. Milelli; A. Minarini; C. Melchiorre; M. Micco; E. Simoni; G. Zuccari; L. Raffaghello; C. Stefanelli; M. Zini; V. Tumiatti
Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease.
2011 M. Rosini; E. Simoni; M. Bartolini; A. Tarozzi; R. Matera; A. Milelli; P. Hrelia; V. Andrisano; M.L. Bolognesi; C. Melchiorre
Exploring the effects of isothiocyanates on chemotherapeutic drugs
2014 Anna Minarini; Andrea Milelli; Carmela Fimognari; Elena Simoni; Eleonora Turrini; Vincenzo Tumiatti
In vivo characterization of ARN14140, a memantine/galantamine-based multi-target compound for Alzheimer's disease
2016 Reggiani, Angelo M.; Simoni, Elena; Caporaso, Roberta; Meunier, Johann; Keller, Emeline; Maurice, Tangui; Minarini, Anna; Rosini, Michela; Cavalli, Andrea
Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush
2008 M. Rosini; E. Simoni; M. Bartolini; A. Cavalli; L. Ceccarini; N. Pascu; D. W. McClymont; A. Tarozzi; M. L. Bolognesi; A. Minarini; V. Tumiatti; V. Andrisano; I. R. Mellor; C. Melchiorre
Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease
2019 Rosini M.; Simoni E.; Caporaso R.; Basagni F.; Catanzaro M.; Abu I.F.; Fagiani F.; Fusco F.; Masuzzo S.; Albani D.; Lanni C.; Mellor I.R.; Minarini A.
Mitochondria-directed antioxidants in Alzheimer's disease.
2010 M. Rosini; E. Simoni; M. L. Bolognesi; C. Bergamini; R. Fato; G. Lenaz; C. Melchiorre
Modulation of Keap1/Nrf2/ARE signaling pathway by curcuma- And garlic-derived hybrids
2020 Serafini M.M.; Catanzaro M.; Fagiani F.; Simoni E.; Caporaso R.; Dacrema M.; Romanoni I.; Govoni S.; Racchi M.; Daglia M.; Rosini M.; Lanni C.
Multi-target Design Strategies in the Context of Alzheimer's Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces
2014 Michela Rosini; Elena Simoni; Anna Minarini; Carlo Melchiorre
Multi-Target-Direcetd Ligands as acetylcholinesterase inhibitors and nicotinic modulators for Alzheimer's disease
2009 M. Rosini; M. Bartolini; E. Simoni; C. Gotti; D. McClymont; ML Bolognesi; A. Minarini; V. Tumiatti; V. Andrisano; I. R. Mellor; C. Melchiorre
Multifunctional Tacrine Derivatives in Alzheimer’s Disease
2013 Anna Minarini; Andrea Milelli; Elena Simoni; Michela Rosini; Maria Laura Bolognesi; Chiara Marchetti; Vincenzo Tumiatti
Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation
2017 Simoni, Elena; Bartolini, Manuela; Abu, Izuddin F; Blockley, Alix; Gotti, Cecilia; Bottegoni, Giovanni; Caporaso, Roberta; Bergamini, Christian; Andrisano, Vincenza; Cavalli, Andrea; Mellor, Ian R; Minarini, Anna; Rosini, Michela
Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics
2016 Rosini, M; Simoni, E; Caporaso, R; Minarini, A
Multitarget-directed drug design strategy: novel hybrid compounds between lipocrine and carvedilol
2007 Rosini M; Simoni E; Bolognesi ML; Andrisano V; Bartolini M; Tarozzi a; Hrelia P; Mellor I; Melchiorre C.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512 | Palermo, G.; Minniti, E.; Greco, M.L.; Riccardi, L.; Simoni, E.; Convertino, M.; Marchetti, C.; R...osini, M.; Sissi, C.; Minarini, A.; De Vivo, M. | 2015-01-01 | CHEMICAL COMMUNICATIONS | - | 1.01 Articolo in rivista | 84. Chem. Comm. 2015.pdf |
| Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate. | Tarozzi, A; Marchetti, C; Nicolini, B; D'Amico, M; Ticchi, N; Pruccoli, L; Tumiatti, V; Simoni, E...; Lodola, A; Mor, M; Milelli, A; Minarini, A. | 2016-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Combining galantamine and memantine in dual-target new chemical entities for the treatment of Alzheimer’s disease | Simoni E.; Daniele S.; Bottegoni G.; Pizzirani D.; Tarozzo G.; Reggiani A.; Trincavelli M.L.; Mar...tini C.; Piomelli D.; Melchiorre C.; Rosini M.; Cavalli A. | 2012-01-01 | - | - | 4.02 Riassunto (Abstract) | - |
| Curcumin analogs as multi-target antioxidants: focus on mitochondria. | E. Simoni; M. Rosini; C. Bergamini; R. Fato; M.L. Bolognesi; A. Cavalli; R. Motterlini; G. Lenaz;... C. Melchiorre | 2010-01-01 | - | s. n. | 4.02 Riassunto (Abstract) | - |
| Cystamine-tacrine dimer: A new multi-target-directed ligand as potential therapeutic agent for Alzheimer's disease treatment. | Minarini A.; Milelli A.; Tumiatti V.; Rosini M.; Simoni E.; Bolognesi M.L.; Andrisano V.; Bartoli...ni M.; Motori E.; Angeloni C.; Hrelia S. | 2012-01-01 | NEUROPHARMACOLOGY | - | 1.01 Articolo in rivista | - |
| Cystamine-tacrine dimer: a new multi-target-directed ligand as potential therapeutic agent for Alzheimer’s disease treatment | A. Minarini; A. Milelli; V. Tumiatti; E. Simoni; M. L. Bolognesi; V. Andrisano; M. Bartolini; E. ...Motori; C. Angeloni ; S. Hrelia; C.Melchiorre | 2011-01-01 | - | 2011 Università del Salento – Coordinamento SIBA- | 4.02 Riassunto (Abstract) | - |
| Design, Synthesis, and biological evaluation of naphtalene diimides derivatives as anticancer agent | A. Milelli; A. Minarini; C. Melchiorre; M. Micco; E. Simoni; G. Zuccari; L. Raffaghello; C. Stefa...nelli; M. Zini; V. Tumiatti | 2010-01-01 | - | s.n | 4.02 Riassunto (Abstract) | - |
| Exploiting the lipoic acid structure in the search for novel multitarget ligands against Alzheimer's disease. | M. Rosini; E. Simoni; M. Bartolini; A. Tarozzi; R. Matera; A. Milelli; P. Hrelia; V. Andrisano; M....L. Bolognesi; C. Melchiorre | 2011-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Exploring the effects of isothiocyanates on chemotherapeutic drugs |
Anna Minarini; Andrea Milelli; Carmela Fimognari; Elena Simoni; Eleonora Turrini; Vincenzo Tumiatti |
2014-01-01 | EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | - | 1.01 Articolo in rivista | - |
| In vivo characterization of ARN14140, a memantine/galantamine-based multi-target compound for Alzheimer's disease | Reggiani, Angelo M.; Simoni, Elena; Caporaso, Roberta; Meunier, Johann; Keller, Emeline; Maurice,... Tangui; Minarini, Anna; Rosini, Michela; Cavalli, Andrea | 2016-01-01 | SCIENTIFIC REPORTS | - | 1.01 Articolo in rivista | 88. Sc.Rep 2016.pdf |
| Inhibition of Acetylcholinesterase, Beta-Amyloid Aggregation, and NMDA Receptors in Alzheimer's Disease: A Promising Direction for the Multi-target-Directed Ligands Gold Rush | M. Rosini; E. Simoni; M. Bartolini; A. Cavalli; L. Ceccarini; N. Pascu; D. W. McClymont; A. Taroz...zi; M. L. Bolognesi; A. Minarini; V. Tumiatti; V. Andrisano; I. R. Mellor; C. Melchiorre | 2008-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease | Rosini M.; Simoni E.; Caporaso R.; Basagni F.; Catanzaro M.; Abu I.F.; Fagiani F.; Fusco F.; Masu...zzo S.; Albani D.; Lanni C.; Mellor I.R.; Minarini A. | 2019-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | EJMECH_11508.pdf |
| Mitochondria-directed antioxidants in Alzheimer's disease. | M. Rosini; E. Simoni; M. L. Bolognesi; C. Bergamini; R. Fato; G. Lenaz; C. Melchiorre | 2010-01-01 | - | s. n. | 4.02 Riassunto (Abstract) | - |
| Modulation of Keap1/Nrf2/ARE signaling pathway by curcuma- And garlic-derived hybrids | Serafini M.M.; Catanzaro M.; Fagiani F.; Simoni E.; Caporaso R.; Dacrema M.; Romanoni I.; Govoni ...S.; Racchi M.; Daglia M.; Rosini M.; Lanni C. | 2020-01-01 | FRONTIERS IN PHARMACOLOGY | - | 1.01 Articolo in rivista | fphar-10-01597.pdf |
| Multi-target Design Strategies in the Context of Alzheimer's Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces | Michela Rosini; Elena Simoni; Anna Minarini; Carlo Melchiorre | 2014-01-01 | NEUROCHEMICAL RESEARCH | - | 1.01 Articolo in rivista | - |
| Multi-Target-Direcetd Ligands as acetylcholinesterase inhibitors and nicotinic modulators for Alzheimer's disease | M. Rosini; M. Bartolini; E. Simoni; C. Gotti; D. McClymont; ML Bolognesi; A. Minarini; V. Tumiatt...i; V. Andrisano; I. R. Mellor; C. Melchiorre | 2009-01-01 | DRUGS OF THE FUTURE | - | 4.02 Riassunto (Abstract) | - |
| Multifunctional Tacrine Derivatives in Alzheimer’s Disease | Anna Minarini; Andrea Milelli; Elena Simoni; Michela Rosini; Maria Laura Bolognesi; Chiara Marche...tti; Vincenzo Tumiatti | 2013-01-01 | CURRENT TOPICS IN MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation | Simoni, Elena; Bartolini, Manuela; Abu, Izuddin F; Blockley, Alix; Gotti, Cecilia; Bottegoni, Gio...vanni; Caporaso, Roberta; Bergamini, Christian; Andrisano, Vincenza; Cavalli, Andrea; Mellor, Ian R; Minarini, Anna; Rosini, Michela | 2017-01-01 | FUTURE MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics | Rosini, M; Simoni, E; Caporaso, R; Minarini, A | 2016-01-01 | FUTURE MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Multitarget-directed drug design strategy: novel hybrid compounds between lipocrine and carvedilol | Rosini M; Simoni E; Bolognesi ML; Andrisano V; Bartolini M; Tarozzi a; Hrelia P; Mellor I; Melchi...orre C. | 2007-01-01 | - | s.n | 4.01 Contributo in Atti di convegno | - |