SIMONI, ELENA
SIMONI, ELENA
DIPARTIMENTO DI FARMACIA E BIOTECNOLOGIE
Assegnisti
Modulation of Keap1/Nrf2/ARE signaling pathway by curcuma- And garlic-derived hybrids
2020 Serafini M.M.; Catanzaro M.; Fagiani F.; Simoni E.; Caporaso R.; Dacrema M.; Romanoni I.; Govoni S.; Racchi M.; Daglia M.; Rosini M.; Lanni C.
Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease
2019 Rosini M.; Simoni E.; Caporaso R.; Basagni F.; Catanzaro M.; Abu I.F.; Fagiani F.; Fusco F.; Masuzzo S.; Albani D.; Lanni C.; Mellor I.R.; Minarini A.
Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation
2017 Simoni, Elena; Bartolini, Manuela; Abu, Izuddin F; Blockley, Alix; Gotti, Cecilia; Bottegoni, Giovanni; Caporaso, Roberta; Bergamini, Christian; Andrisano, Vincenza; Cavalli, Andrea; Mellor, Ian R; Minarini, Anna; Rosini, Michela
Nature-inspired Nrf2 activators in retinal pigment epithelial cells: a source for therapeutics in age-related macular degeneration
2017 AMADIO M, Serafini M M, Marchesi N, Catanzaro M, Fagiani F, Simoni E, Pascale A, Rosini M, Lanni C
Quinazoline based α1-adrenoreceptor antagonists with potent antiproliferative activity in human prostate cancer cell lines
2017 Maestri, Valentina; Tarozzi, Andrea; Simoni, Elena; Cilia, Antonio; Poggesi, Elena; Naldi, Marina; Nicolini, Benedetta; Pruccoli, Letizia; Rosini, Michela; Minarini, Anna
Targeting the Nrf2/Amyloid-Beta Liaison in Alzheimer's Disease: A Rational Approach
2017 Simoni, Elena; Serafini, Melania M; Caporaso, Roberta; Marchetti, Chiara; Racchi, Marco; Minarini, Anna; Bartolini, Manuela; Lanni, Cristina; Rosini, Michela
Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate.
2016 Tarozzi, A; Marchetti, C; Nicolini, B; D'Amico, M; Ticchi, N; Pruccoli, L; Tumiatti, V; Simoni, E; Lodola, A; Mor, M; Milelli, A; Minarini, A.
In vivo characterization of ARN14140, a memantine/galantamine-based multi-target compound for Alzheimer's disease
2016 Reggiani, Angelo M.; Simoni, Elena; Caporaso, Roberta; Meunier, Johann; Keller, Emeline; Maurice, Tangui; Minarini, Anna; Rosini, Michela; Cavalli, Andrea
Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics
2016 Rosini, M; Simoni, E; Caporaso, R; Minarini, A
Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease
2016 Simoni, Elena; Serafini, Melania M.; Bartolini, Manuela; Caporaso, Roberta; Pinto, Antonella; Necchi, Daniela; Fiori, Jessica; Vincenza, Andrisano; Minarini, Anna; Lanni, Cristina; Rosini, Michela
Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease
2016 Simoni, Elena; Caporaso, Roberta; Bergamini, Christian; Fiori, Jessica; Fato, Romana; Miszta, Przemyslaw; Filipek, Sławomir; Caraci, Filippo; Giuffrida, Maria Laura; Andrisano, Vincenza; Minarini, Anna; Bartolini, Manuela; Rosini, Michela
An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512
2015 Palermo, G.; Minniti, E.; Greco, M.L.; Riccardi, L.; Simoni, E.; Convertino, M.; Marchetti, C.; Rosini, M.; Sissi, C.; Minarini, A.; De Vivo, M.
Exploring the effects of isothiocyanates on chemotherapeutic drugs
2014 Anna Minarini; Andrea Milelli; Carmela Fimognari; Elena Simoni; Eleonora Turrini; Vincenzo Tumiatti
Multi-target Design Strategies in the Context of Alzheimer's Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces
2014 Michela Rosini; Elena Simoni; Anna Minarini; Carlo Melchiorre
Natural-product-inspired modulators of Alzheimer’s disease: focus on amyloid and oxidative stress
2014 Rosini, M.; Simoni, E.; Lanni, C.; Bartolini, M.; Pinto, A.; Fiori, J.; Andrisano, V.; Racchi, M.; Minarini, A.
Oxidative stress in Alzheimer’s disease: are we connecting the dots?
2014 Michela Rosini; Elena Simoni; Andrea Milelli; Anna Minarini; Carlo Melchiorre
Multifunctional Tacrine Derivatives in Alzheimer’s Disease
2013 Anna Minarini; Andrea Milelli; Elena Simoni; Michela Rosini; Maria Laura Bolognesi; Chiara Marchetti; Vincenzo Tumiatti
Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease
2013 Federica Prati;Manuela Bartolini;Elena Simoni;Angela De Simone;Antonella Pinto;Vincenza Andrisano;Maria Laura Bolognesi
The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon
2013 Michela Rosini; Elena Simoni; Manuela Bartolini; Elena Soriano; José Marco-Contelles; Vincenza Andrisano; Barbara Monti; Manfred Windisch; Birgit Hutter-Paier; David W. McClymont; Ian R. Mellor; Maria Laura Bolognesi
Combining galantamine and memantine in dual-target new chemical entities for the treatment of Alzheimer’s disease
2012 Simoni E.; Daniele S.; Bottegoni G.; Pizzirani D.; Tarozzo G.; Reggiani A.; Trincavelli M.L.; Martini C.; Piomelli D.; Melchiorre C.; Rosini M.; Cavalli A.
| Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
|---|---|---|---|---|---|---|
| Modulation of Keap1/Nrf2/ARE signaling pathway by curcuma- And garlic-derived hybrids | Serafini M.M.; Catanzaro M.; Fagiani F.; Simoni E.; Caporaso R.; Dacrema M.; Romanoni I.; Govoni ...S.; Racchi M.; Daglia M.; Rosini M.; Lanni C. | 2020-01-01 | FRONTIERS IN PHARMACOLOGY | - | 1.01 Articolo in rivista | fphar-10-01597.pdf |
| Merging memantine and ferulic acid to probe connections between NMDA receptors, oxidative stress and amyloid-β peptide in Alzheimer's disease | Rosini M.; Simoni E.; Caporaso R.; Basagni F.; Catanzaro M.; Abu I.F.; Fagiani F.; Fusco F.; Masu...zzo S.; Albani D.; Lanni C.; Mellor I.R.; Minarini A. | 2019-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | EJMECH_11508.pdf |
| Multitarget drug design strategy in Alzheimer's disease: focus on cholinergic transmission and amyloid-beta aggregation | Simoni, Elena; Bartolini, Manuela; Abu, Izuddin F; Blockley, Alix; Gotti, Cecilia; Bottegoni, Gio...vanni; Caporaso, Roberta; Bergamini, Christian; Andrisano, Vincenza; Cavalli, Andrea; Mellor, Ian R; Minarini, Anna; Rosini, Michela | 2017-01-01 | FUTURE MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Nature-inspired Nrf2 activators in retinal pigment epithelial cells: a source for therapeutics in age-related macular degeneration |
AMADIO M, Serafini M M, Marchesi N, Catanzaro M, Fagiani F, Simoni E, Pascale A, Rosini M, Lanni C |
2017-01-01 | - | - | 4.02 Riassunto (Abstract) | - |
| Quinazoline based α1-adrenoreceptor antagonists with potent antiproliferative activity in human prostate cancer cell lines | Maestri, Valentina; Tarozzi, Andrea; Simoni, Elena; Cilia, Antonio; Poggesi, Elena; Naldi, Marina...; Nicolini, Benedetta; Pruccoli, Letizia; Rosini, Michela; Minarini, Anna | 2017-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Targeting the Nrf2/Amyloid-Beta Liaison in Alzheimer's Disease: A Rational Approach | Simoni, Elena; Serafini, Melania M; Caporaso, Roberta; Marchetti, Chiara; Racchi, Marco; Minarini..., Anna; Bartolini, Manuela; Lanni, Cristina; Rosini, Michela | 2017-01-01 | ACS CHEMICAL NEUROSCIENCE | - | 1.01 Articolo in rivista | - |
| Combined inhibition of the EGFR/AKT pathways by a novel conjugate of quinazoline with isothiocyanate. | Tarozzi, A; Marchetti, C; Nicolini, B; D'Amico, M; Ticchi, N; Pruccoli, L; Tumiatti, V; Simoni, E...; Lodola, A; Mor, M; Milelli, A; Minarini, A. | 2016-01-01 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| In vivo characterization of ARN14140, a memantine/galantamine-based multi-target compound for Alzheimer's disease | Reggiani, Angelo M.; Simoni, Elena; Caporaso, Roberta; Meunier, Johann; Keller, Emeline; Maurice,... Tangui; Minarini, Anna; Rosini, Michela; Cavalli, Andrea | 2016-01-01 | SCIENTIFIC REPORTS | - | 1.01 Articolo in rivista | 88. Sc.Rep 2016.pdf |
| Multitarget strategies in Alzheimer's disease: benefits and challenges on the road to therapeutics | Rosini, M; Simoni, E; Caporaso, R; Minarini, A | 2016-01-01 | FUTURE MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Nature-Inspired Multifunctional Ligands: Focusing on Amyloid-Based Molecular Mechanisms of Alzheimer’s Disease | Simoni, Elena; Serafini, Melania M.; Bartolini, Manuela; Caporaso, Roberta; Pinto, Antonella; Nec...chi, Daniela; Fiori, Jessica; Vincenza, Andrisano; Minarini, Anna; Lanni, Cristina; Rosini, Michela | 2016-01-01 | CHEMMEDCHEM | - | 1.01 Articolo in rivista | Simoni E. et al..pdf |
| Polyamine Conjugation as a Promising Strategy To Target Amyloid Aggregation in the Framework of Alzheimer’s Disease | Simoni, Elena; Caporaso, Roberta; Bergamini, Christian; Fiori, Jessica; Fato, Romana; Miszta, Prz...emyslaw; Filipek, Sławomir; Caraci, Filippo; Giuffrida, Maria Laura; Andrisano, Vincenza; Minarini, Anna; Bartolini, Manuela; Rosini, Michela | 2016-01-01 | ACS MEDICINAL CHEMISTRY LETTERS | - | 1.01 Articolo in rivista | - |
| An optimized polyamine moiety boosts the potency of human type II topoisomerase poisons as quantified by comparative analysis centered on the clinical candidate F14512 | Palermo, G.; Minniti, E.; Greco, M.L.; Riccardi, L.; Simoni, E.; Convertino, M.; Marchetti, C.; R...osini, M.; Sissi, C.; Minarini, A.; De Vivo, M. | 2015-01-01 | CHEMICAL COMMUNICATIONS | - | 1.01 Articolo in rivista | 84. Chem. Comm. 2015.pdf |
| Exploring the effects of isothiocyanates on chemotherapeutic drugs |
Anna Minarini; Andrea Milelli; Carmela Fimognari; Elena Simoni; Eleonora Turrini; Vincenzo Tumiatti |
2014-01-01 | EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY | - | 1.01 Articolo in rivista | - |
| Multi-target Design Strategies in the Context of Alzheimer's Disease: Acetylcholinesterase Inhibition and NMDA Receptor Antagonism as the Driving Forces | Michela Rosini; Elena Simoni; Anna Minarini; Carlo Melchiorre | 2014-01-01 | NEUROCHEMICAL RESEARCH | - | 1.01 Articolo in rivista | - |
| Natural-product-inspired modulators of Alzheimer’s disease: focus on amyloid and oxidative stress | Rosini, M.; Simoni, E.; Lanni, C.; Bartolini, M.; Pinto, A.; Fiori, J.; Andrisano, V.; Racchi, M....; Minarini, A. | 2014-01-01 | - | - | 4.02 Riassunto (Abstract) | - |
| Oxidative stress in Alzheimer’s disease: are we connecting the dots? | Michela Rosini; Elena Simoni; Andrea Milelli; Anna Minarini; Carlo Melchiorre | 2014-01-01 | JOURNAL OF MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Multifunctional Tacrine Derivatives in Alzheimer’s Disease | Anna Minarini; Andrea Milelli; Elena Simoni; Michela Rosini; Maria Laura Bolognesi; Chiara Marche...tti; Vincenzo Tumiatti | 2013-01-01 | CURRENT TOPICS IN MEDICINAL CHEMISTRY | - | 1.01 Articolo in rivista | - |
| Quinones bearing non-steroidal anti-inflammatory fragments as multitarget ligands for Alzheimer’s disease | Federica Prati;Manuela Bartolini;Elena Simoni;Angela De Simone;Antonella Pinto;Vincenza Andrisano...;Maria Laura Bolognesi | 2013-01-01 | BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | - | 1.01 Articolo in rivista | - |
| The bivalent ligand approach as a tool for improving the in vitro anti-Alzheimer multitarget profile of dimebon | Michela Rosini; Elena Simoni; Manuela Bartolini; Elena Soriano; José Marco-Contelles; Vincenza An...drisano; Barbara Monti; Manfred Windisch; Birgit Hutter-Paier; David W. McClymont; Ian R. Mellor; Maria Laura Bolognesi | 2013-01-01 | CHEMMEDCHEM | - | 1.01 Articolo in rivista | - |
| Combining galantamine and memantine in dual-target new chemical entities for the treatment of Alzheimer’s disease | Simoni E.; Daniele S.; Bottegoni G.; Pizzirani D.; Tarozzo G.; Reggiani A.; Trincavelli M.L.; Mar...tini C.; Piomelli D.; Melchiorre C.; Rosini M.; Cavalli A. | 2012-01-01 | - | - | 4.02 Riassunto (Abstract) | - |