TONELLI, ROBERTO
TONELLI, ROBERTO
DIPARTIMENTO DI FARMACIA E BIOTECNOLOGIE
Ricercatori
Preclinical Pharmacokinetics in Tumors and Normal Tissues of the Antigene PNA Oligonucleotide MYCN-Inhibitor BGA002
2024 Scardovi, Anna Lisa; Bartolucci, Damiano; Montemurro, Luca; Bortolotti, Sonia; Angelucci, Silvia; Amadesi, Camilla; Nieddu, Giammario; Oosterholt, Sean; Cerisoli, Lucia; Della Pasqua, Oscar; Hrelia, Patrizia; Tonelli, Roberto
Antigene MYCN Silencing by BGA002 Inhibits SCLC Progression Blocking mTOR Pathway and Overcomes Multidrug Resistance
2023 Bortolotti, Sonia; Angelucci, Silvia; Montemurro, Luca; Bartolucci, Damiano; Raieli, Salvatore; Lampis, Silvia; Amadesi, Camilla; Scardovi, Annalisa; Nieddu, Giammario; Cerisoli, Lucia; Paganelli, Francesca; Chiarini, Francesca; Teti, Gabriella; Falconi, Mirella; Pession, Andrea; Hrelia, Patrizia; Tonelli, Roberto
MYCN Impact on High-Risk Neuroblastoma: From Diagnosis and Prognosis to Targeted Treatment
2022 Bartolucci D.; Montemurro L.; Raieli S.; Lampis S.; Pession A.; Hrelia P.; Tonelli R.
Precision Anti-Cancer Medicines by Oligonucleotide Therapeutics in Clinical Research Targeting Undruggable Proteins and Non-Coding RNAs
2022 Bartolucci D.; Pession A.; Hrelia P.; Tonelli R.
The MYCN inhibitor BGA002 restores the retinoic acid response leading to differentiation or apoptosis by the mTOR block in MYCN-amplified neuroblastoma
2022 Lampis S.; Raieli S.; Montemurro L.; Bartolucci D.; Amadesi C.; Bortolotti S.; Angelucci S.; Scardovi A.L.; Nieddu G.; Cerisoli L.; Paganelli F.; Valente S.; Fischer M.; Martelli A.M.; Pasquinelli G.; Pession A.; Hrelia P.; Tonelli R.
MYCN Drives a Tumor Immunosuppressive Environment Which Impacts Survival in Neuroblastoma
2021 Raieli S.; Di Renzo D.; Lampis S.; Amadesi C.; Montemurro L.; Pession A.; Hrelia P.; Fischer M.; Tonelli R.
Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma
2020 Moreno L.; Barone G.; DuBois S.G.; Molenaar J.; Fischer M.; Schulte J.; Eggert A.; Schleiermacher G.; Speleman F.; Chesler L.; Geoerger B.; Hogarty M.D.; Irwin M.S.; Bird N.; Blanchard G.B.; Buckland S.; Caron H.; Davis S.; De Wilde B.; Deubzer H.E.; Dolman E.; Eilers M.; George R.E.; George S.; Jaroslav; Maris J.M.; Marshall L.; Merchant M.; Mortimer P.; Owens C.; Philpott A.; Poon E.; Shay J.W.; Tonelli R.; Valteau-Couanet D.; Vassal G.; Park J.R.; Pearson A.D.J.
A novel MYCN-specific antigene oligonucleotide deregulates mitochondria and inhibits tumor growth in MYCN-amplified neuroblastoma
2019 Montemurro L.; Raieli S.; Angelucci S.; Bartolucci D.; Amadesi C.; Lampis S.; Scardovi A.L.; Venturelli L.; Nieddu G.; Cerisoli L.; Fischer M.; Teti G.; Falconi M.; Pession A.; Hrelia P.; Tonelli R.
MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia
2014 A. Astolfi; F. Vendemini; M. Urbini; F. Melchionda; R. Masetti; M. Franzoni; V. Libri; S. Serravalle; M. Togni; L. Montemurro; R. Rondelli; G. Paone; D. Bressanin; F. Chiarini; A.M. Martelli; R. Tonelli; A. Pession.
Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice.
2014 Bergantin E; Quarta C; Nanni C; Fanti S; Pession A; Cantelli-Forti G; Tonelli R; Hrelia P
Molecular Imaging of Neuroblastoma Progression in TH-MYCN Transgenic Mice
2013 Carmelo Quarta; Erika Cantelli; Cristina Nanni; Valentina Ambrosini; Daniela D’ambrosio; Korinne Di Leo; Silvia Angelucci; Federico Zagni; Filippo Lodi; Mario Marengo; William A. Weiss; Andrea Pession; Roberto Tonelli; Stefano Fanti
Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy
2012 R. Tonelli; A. McIntyre; C. Camerin; Z.S. Walters; K. Di Leo; J. Selfe; S. Purgato; E. Missiaglia; A. Tortori; J. Renshaw; A. Astolfi; K.R. Taylor; S. Serravalle; R. Bishop; C. Nanni; L.J. Valentijn; A. Faccini; I. Leuschner; S. Formica; Jorge S Reis-Filho9; V. Ambrosini; K. Thway; M. Franzoni; B. Summersgill; R. Marchelli; P. Hrelia; G. Cantelli-Forti; S. Fanti; R. Corradini; A. Pession; J. Shipley
Feasibility and safety of adoptive immunotherapy with ex vivogenerated autologous, cytotoxic T lymphocytes in patients with solid tumor
2012 D MONTAGNA; I TURIN; R SCHIAVO; E MONTINI; N ZAFFARONI; R VILLA; S SECONDINO; I SCHIAVETTO; L CALIOGNA; F LOCATELLI; VIRGINIA LIBRI; ANDREA PESSION; R TONELLI; R MACCARIO; S SIENA; P PEDRAZZOLI
Generation and characterization of bioluminescent xenograft mouse models of MLL-related acute leukemias and in vivo evaluation of luciferase-targeting siRNA nanoparticles
2012 FAZZINA R.; LOMBARDINI L.; MEZZANOTTE L.; RODA A.; HRELIA P; PESSION A.; TONELLI R.
Transient suppression of MLH1 allows effective single-nucleotide substitution by single-stranded DNA oligonucleotides
2011 M. Dekker; S. de Vries; M. Aarts; R. Dekker; C Brouwersa; O. Wiebenga; N. de Wind; E. Cantelli; R. Tonelli; H te Riele
A Peptide Nucleic Acid Embedding a Pseudopeptide Nuclear Localization Sequence in the Backbone Behaves as a Peptide Mimic
2010 Sforza S.; Tedeschi T.; Calabretta A.; Corradini R.; Camerin C.; Tonelli R.; Pession A.; Marchelli R.
Chitosan nanoparticles for siRNA delivery: influence of nanoparticle composition on gene silencing efficiency
2010 R. Tonelli; B. Luppi; L. Lombardini; S. Rampelli; P. Hrelia; A. Pession
In vivo bioluminescence imaging of murine xenograft cancer models with a red-shifted thermostable luciferase.
2010 Mezzanotte L; Fazzina R; Michelini E; Tonelli R; Pession A; Branchini B; Roda A
Down-regulation of HOXA4, HOXA7, HOXA10, HOXA11 and MEIS1 during monocyte-macrophage differentiation in THP-1 cells
2009 V MARTINO; A BIANCHERA; L REIA; O BUSSOLATI; R FAZZINA; F MARINO; L MONTEMURRO; R TONELLI; A PESSION; GC GAZZOLA; R SALA
Circular dichroism study of DNA binding by a potential anticancer peptide nucleic acid targeted against the MYCN oncogene.
2008 Faccini A; Tortori A; Tedeschi T; Sforza S; Tonelli R; Pession A; Corradini R; Marchelli R.
Titolo | Autore(i) | Anno | Periodico | Editore | Tipo | File |
---|---|---|---|---|---|---|
Preclinical Pharmacokinetics in Tumors and Normal Tissues of the Antigene PNA Oligonucleotide MYCN-Inhibitor BGA002 | Scardovi, Anna Lisa; Bartolucci, Damiano; Montemurro, Luca; Bortolotti, Sonia; Angelucci, Silvia;... Amadesi, Camilla; Nieddu, Giammario; Oosterholt, Sean; Cerisoli, Lucia; Della Pasqua, Oscar; Hrelia, Patrizia; Tonelli, Roberto | 2024-01-01 | NUCLEIC ACID THERAPEUTICS | - | 1.01 Articolo in rivista | - |
Antigene MYCN Silencing by BGA002 Inhibits SCLC Progression Blocking mTOR Pathway and Overcomes Multidrug Resistance | Bortolotti, Sonia; Angelucci, Silvia; Montemurro, Luca; Bartolucci, Damiano; Raieli, Salvatore; L...ampis, Silvia; Amadesi, Camilla; Scardovi, Annalisa; Nieddu, Giammario; Cerisoli, Lucia; Paganelli, Francesca; Chiarini, Francesca; Teti, Gabriella; Falconi, Mirella; Pession, Andrea; Hrelia, Patrizia; Tonelli, Roberto | 2023-01-01 | CANCERS | - | 1.01 Articolo in rivista | cancers-15-00990.pdf |
MYCN Impact on High-Risk Neuroblastoma: From Diagnosis and Prognosis to Targeted Treatment | Bartolucci D.; Montemurro L.; Raieli S.; Lampis S.; Pession A.; Hrelia P.; Tonelli R. | 2022-01-01 | CANCERS | - | 1.01 Articolo in rivista | cancers-14-04421.pdf |
Precision Anti-Cancer Medicines by Oligonucleotide Therapeutics in Clinical Research Targeting Undruggable Proteins and Non-Coding RNAs | Bartolucci D.; Pession A.; Hrelia P.; Tonelli R. | 2022-01-01 | PHARMACEUTICS | - | 1.01 Articolo in rivista | Bartolucci D, et al Pharmaceutics-14-01453.pdf |
The MYCN inhibitor BGA002 restores the retinoic acid response leading to differentiation or apoptosis by the mTOR block in MYCN-amplified neuroblastoma | Lampis S.; Raieli S.; Montemurro L.; Bartolucci D.; Amadesi C.; Bortolotti S.; Angelucci S.; Scar...dovi A.L.; Nieddu G.; Cerisoli L.; Paganelli F.; Valente S.; Fischer M.; Martelli A.M.; Pasquinelli G.; Pession A.; Hrelia P.; Tonelli R. | 2022-01-01 | JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH | - | 1.01 Articolo in rivista | Lampis_et_al-2022-Journal_of_Experimental_&_Clinical_Cancer_Research.pdf; 19688410.zip |
MYCN Drives a Tumor Immunosuppressive Environment Which Impacts Survival in Neuroblastoma | Raieli S.; Di Renzo D.; Lampis S.; Amadesi C.; Montemurro L.; Pession A.; Hrelia P.; Fischer M.; ...Tonelli R. | 2021-01-01 | FRONTIERS IN ONCOLOGY | - | 1.01 Articolo in rivista | Frontiers in Oncology 25 February 2021.pdf; file supplemenatari.zip |
Accelerating drug development for neuroblastoma: Summary of the Second Neuroblastoma Drug Development Strategy forum from Innovative Therapies for Children with Cancer and International Society of Paediatric Oncology Europe Neuroblastoma | Moreno L.; Barone G.; DuBois S.G.; Molenaar J.; Fischer M.; Schulte J.; Eggert A.; Schleiermacher... G.; Speleman F.; Chesler L.; Geoerger B.; Hogarty M.D.; Irwin M.S.; Bird N.; Blanchard G.B.; Buckland S.; Caron H.; Davis S.; De Wilde B.; Deubzer H.E.; Dolman E.; Eilers M.; George R.E.; George S.; Jaroslav; Maris J.M.; Marshall L.; Merchant M.; Mortimer P.; Owens C.; Philpott A.; Poon E.; Shay J.W.; Tonelli R.; Valteau-Couanet D.; Vassal G.; Park J.R.; Pearson A.D.J. | 2020-01-01 | EUROPEAN JOURNAL OF CANCER | - | 1.01 Articolo in rivista | - |
A novel MYCN-specific antigene oligonucleotide deregulates mitochondria and inhibits tumor growth in MYCN-amplified neuroblastoma | Montemurro L.; Raieli S.; Angelucci S.; Bartolucci D.; Amadesi C.; Lampis S.; Scardovi A.L.; Vent...urelli L.; Nieddu G.; Cerisoli L.; Fischer M.; Teti G.; Falconi M.; Pession A.; Hrelia P.; Tonelli R. | 2019-01-01 | CANCER RESEARCH | - | 1.01 Articolo in rivista | montemurro2019.pdf |
MYCN is a novel oncogenic target in pediatric T-cell Acute Lymphoblastic Leukemia | A. Astolfi; F. Vendemini; M. Urbini; F. Melchionda; R. Masetti; M. Franzoni; V. Libri; S. Serrava...lle; M. Togni; L. Montemurro; R. Rondelli; G. Paone; D. Bressanin; F. Chiarini; A.M. Martelli; R. Tonelli; A. Pession. | 2014-01-01 | ONCOTARGET | - | 1.01 Articolo in rivista | - |
Sulforaphane induces apoptosis in rhabdomyosarcoma and restores TRAIL-sensitivity in the aggressive alveolar subtype leading to tumor elimination in mice. | Bergantin E; Quarta C; Nanni C; Fanti S; Pession A; Cantelli-Forti G; Tonelli R; Hrelia P | 2014-01-01 | CANCER BIOLOGY & THERAPY | - | 1.01 Articolo in rivista | - |
Molecular Imaging of Neuroblastoma Progression in TH-MYCN Transgenic Mice | Carmelo Quarta; Erika Cantelli; Cristina Nanni; Valentina Ambrosini; Daniela D’ambrosio; Korinne ...Di Leo; Silvia Angelucci; Federico Zagni; Filippo Lodi; Mario Marengo; William A. Weiss; Andrea Pession; Roberto Tonelli; Stefano Fanti | 2013-01-01 | MOLECULAR IMAGING AND BIOLOGY | - | 1.01 Articolo in rivista | - |
Antitumor Activity of Sustained N-Myc Reduction in Rhabdomyosarcomas and Transcriptional Block by Antigene Therapy | R. Tonelli; A. McIntyre; C. Camerin; Z.S. Walters; K. Di Leo; J. Selfe; S. Purgato; E. Missiaglia...; A. Tortori; J. Renshaw; A. Astolfi; K.R. Taylor; S. Serravalle; R. Bishop; C. Nanni; L.J. Valentijn; A. Faccini; I. Leuschner; S. Formica; Jorge S Reis-Filho9; V. Ambrosini; K. Thway; M. Franzoni; B. Summersgill; R. Marchelli; P. Hrelia; G. Cantelli-Forti; S. Fanti; R. Corradini; A. Pession; J. Shipley | 2012-01-01 | CLINICAL CANCER RESEARCH | - | 1.01 Articolo in rivista | - |
Feasibility and safety of adoptive immunotherapy with ex vivogenerated autologous, cytotoxic T lymphocytes in patients with solid tumor |
D MONTAGNA; I TURIN; R SCHIAVO; E MONTINI; N ZAFFARONI; R VILLA; S SECONDINO; I SCHIAVETTO; L CAL...IOGNA; F LOCATELLI; VIRGINIA LIBRI; ANDREA PESSION; R TONELLI; R MACCARIO; S SIENA; P PEDRAZZOLI |
2012-01-01 | CYTOTHERAPY | - | 1.01 Articolo in rivista | - |
Generation and characterization of bioluminescent xenograft mouse models of MLL-related acute leukemias and in vivo evaluation of luciferase-targeting siRNA nanoparticles | FAZZINA R.; LOMBARDINI L.; MEZZANOTTE L.; RODA A.; HRELIA P; PESSION A.; TONELLI R. | 2012-01-01 | INTERNATIONAL JOURNAL OF ONCOLOGY | - | 1.01 Articolo in rivista | - |
Transient suppression of MLH1 allows effective single-nucleotide substitution by single-stranded DNA oligonucleotides |
M. Dekker; S. de Vries; M. Aarts; R. Dekker; C Brouwersa; O. Wiebenga; N. de Wind; E. Cantelli; R.... Tonelli; H te Riele |
2011-01-01 | MUTATION RESEARCH | - | 1.01 Articolo in rivista | - |
A Peptide Nucleic Acid Embedding a Pseudopeptide Nuclear Localization Sequence in the Backbone Behaves as a Peptide Mimic | Sforza S.; Tedeschi T.; Calabretta A.; Corradini R.; Camerin C.; Tonelli R.; Pession A.; Marchell...i R. | 2010-01-01 | EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | - | 1.01 Articolo in rivista | - |
Chitosan nanoparticles for siRNA delivery: influence of nanoparticle composition on gene silencing efficiency | R. Tonelli; B. Luppi; L. Lombardini; S. Rampelli; P. Hrelia; A. Pession | 2010-01-01 | - | s.n | 4.02 Riassunto (Abstract) | - |
In vivo bioluminescence imaging of murine xenograft cancer models with a red-shifted thermostable luciferase. | Mezzanotte L; Fazzina R; Michelini E; Tonelli R; Pession A; Branchini B; Roda A | 2010-01-01 | MOLECULAR IMAGING AND BIOLOGY | - | 1.01 Articolo in rivista | - |
Down-regulation of HOXA4, HOXA7, HOXA10, HOXA11 and MEIS1 during monocyte-macrophage differentiation in THP-1 cells |
V MARTINO; A BIANCHERA; L REIA; O BUSSOLATI; R FAZZINA; F MARINO; L MONTEMURRO; R TONELLI; A PESS...ION; GC GAZZOLA; R SALA |
2009-01-01 | MOLECULAR MEDICINE REPORTS | - | 1.01 Articolo in rivista | - |
Circular dichroism study of DNA binding by a potential anticancer peptide nucleic acid targeted against the MYCN oncogene. | Faccini A; Tortori A; Tedeschi T; Sforza S; Tonelli R; Pession A; Corradini R; Marchelli R. | 2008-01-01 | CHIRALITY | - | 1.01 Articolo in rivista | - |