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Current Research Information System

IRIS è l'implementazione del sistema CRIS dell'università di Bologna che facilita la raccolta e la gestione dei dati relativi alle attività e ai prodotti della ricerca. Fornisce a ricercatori, amministratori e valutatori gli strumenti per documentare e monitorare i risultati della ricerca e per aumentarne la visibilità.

Prodotti recenti

Efficient clofilium tosylate-mediated rescue of POLG-related disease phenotypes in zebrafish

The DNA polymerase gamma (Polg) is a nuclear-encoded enzyme involved in DNA replication in animal mitochondria. In humans, mutations in the POLG gene underlie a set of mitochondrial diseases characterized by mitochondrial DNA (mtDNA) depletion or deletion and multiorgan defects, named POLG disorders, for which an effective therapy is still needed. By applying antisense strategies, ENU- and CRISPR/Cas9-based mutagenesis, we have generated embryonic, larval-lethal and adult-viable zebrafish Pol...

LPHN2 inhibits vascular permeability by differential control of endothelial cell adhesion

Dynamic modulation of endothelial cell-to-cell and cell–to–extracellular matrix (ECM) adhesion is essential for blood vessel patterning and functioning. Yet the molecular mechanisms involved in this process have not been completely deciphered. We identify the adhesion G protein–coupled receptor (ADGR) Latrophilin 2 (LPHN2) as a novel determinant of endothelial cell (EC) adhesion and barrier function. In cultured ECs, endogenous LPHN2 localizes at ECM contacts, signals through cAMP/Rap1, and i...

Oxidative pentose phosphate pathway controls vascular mural cell coverage by regulating extracellular matrix composition

Vascular mural cells (vMCs) play an essential role in the development and maturation of the vasculature by promoting vessel stabilization through their interactions with endothelial cells. Whether endothelial metabolism influences mural cell recruitment and differentiation is unknown. Here, we show that the oxidative pentose phosphate pathway (oxPPP) in endothelial cells is required for establishing vMC coverage of the dorsal aorta during early vertebrate development in zebrafish and mice. We...

Y705 and S727 are required for mitochondrial import and transcriptional activities of STAT3 and regulate proliferation of embryonic and tissue stem cells

The STAT3 transcription factor, acting both in the nucleus and mitochondria, maintains embryonic stem cell pluripotency and promotes their proliferation. In this work, using zebrafish, we determined in vivo that mitochondrial STAT3 regulates mtDNA transcription in embryonic and larval stem cell niches and that this activity affects their proliferation rates. As a result, we demonstrated that STAT3 import inside mitochondria requires Y705 phosphorylation by Jak, while its mitochondrial transcr...

Zebrafish polg2 knock-out recapitulates human POLG-disorders; implications for drug treatment

The human mitochondrial DNA polymerase gamma is a holoenzyme, involved in mitochondrial DNA (mtDNA) replication and maintenance, composed of a catalytic subunit (POLG) and a dimeric accessory subunit (POLG2) conferring processivity. Mutations in POLG or POLG2 cause POLG-related diseases in humans, leading to a subset of Mendelian-inherited mitochondrial disorders characterized by mtDNA depletion (MDD) or accumulation of multiple deletions, presenting multi-organ defects and often leading to p...

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Rivista
  • ASTRONOMY & ASTROPHYSICS1482
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  • PHYSICS LETTERS. SECTION B889
  • PLOS ONE850
  • THE ASTROPHYSICAL JOURNAL838
  • PHYSICAL REVIEW D, PARTICLES, FIE...799
  • THE EUROPEAN PHYSICAL JOURNAL. C,...776
  • SCIENTIFIC REPORTS654
Serie
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  • AMS ACTA94
  • IFAC-PAPERSONLINE85
Data di pubblicazione
  • In stampa/Attività in corso2724
  • 2020 - 202567726
  • 2010 - 2019147132
  • 2000 - 200993294
  • 1990 - 19993246
  • 1980 - 1989535
  • 1970 - 197929
  • 1967 - 19691
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Prodotti più scaricati
  • Il diabete mellito nel cane: Terapia e monitoraggio
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  • Blockchain-based traceability in Agri-Food supply chain management: A practical implementation
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  • Inflammaging: a new immune–metabolic viewpoint for age-related diseases
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  • La classe plurilingue in Italia: sfide e opportunità
  • Attitudes towards Roma people and migrants: a comparison through a Bayesian multidimensional IRT model
  • Promuovere l'autonomia e l'autodeterminazione di giovani e adulti con disabilità intellettiva : indicazioni metodologiche

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pubblicazioni 2023