Ghrelin is an endogeneous ligand for growth hormone secretagogue receptor and its principal synthesis site is stomach (Kojima et al., 1999). Plasma ghrelin levels are reduced in obese subjects and are increased in anorexic subjects (Haqq et al., 2003). It has also been proposed that ghrelin could influence growth and physical development (Whatmore et al., 2003). The initiation of puberty has been reported to increase leptin and decrease ghrelin (Haqq et al., 2003; Whatmore et al., 2003) concentrations in blood. However, knowledge of ghrelin concentrations through childhood have not yet been fully defined, especially the effect of regular high energy expenditure on ghrelin concentration during pubertal development in boys. Accelerated growth and changes in fat, muscle and bone mass take place during puberty. These changes are mediated by many hormones, including leptin, insulinlike growth factor-I (IGF-1) and sex hormones (Yilmatz et al., 2005). Therefore, the present cross-sectional study aimed to assess the influence of regular physical activity on ghrelin concentrations and the interrelationships between ghrelin and metabolic and biochemical parameters in pubertal and prepubertal boys.
Maestu J., Cicchella A., Tillmann V., Latt E., Haljaste K., Purge P., et al. (2008). Relationships between ghrelin concentration and metabolic parameters in boys. London & New York : Taylor and Francis [10.4324/9780203890851].
Relationships between ghrelin concentration and metabolic parameters in boys
Cicchella A.Investigation
;
2008
Abstract
Ghrelin is an endogeneous ligand for growth hormone secretagogue receptor and its principal synthesis site is stomach (Kojima et al., 1999). Plasma ghrelin levels are reduced in obese subjects and are increased in anorexic subjects (Haqq et al., 2003). It has also been proposed that ghrelin could influence growth and physical development (Whatmore et al., 2003). The initiation of puberty has been reported to increase leptin and decrease ghrelin (Haqq et al., 2003; Whatmore et al., 2003) concentrations in blood. However, knowledge of ghrelin concentrations through childhood have not yet been fully defined, especially the effect of regular high energy expenditure on ghrelin concentration during pubertal development in boys. Accelerated growth and changes in fat, muscle and bone mass take place during puberty. These changes are mediated by many hormones, including leptin, insulinlike growth factor-I (IGF-1) and sex hormones (Yilmatz et al., 2005). Therefore, the present cross-sectional study aimed to assess the influence of regular physical activity on ghrelin concentrations and the interrelationships between ghrelin and metabolic and biochemical parameters in pubertal and prepubertal boys.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
