The present invention is related to a multifunctional system bearing a ligand capable of recognizing 5 tumor cells or tumor-associated or inflammation-associated component and linked to a metal nanoparticle. More specifically, the multifunctional system of the invention comprises a nucleotide aptamer or a variant thereof that binds to the alpha 5 subunit of integrin and a metal nanoparticle, wherein said aptamer optionally comprises at least one modification capable of enhancing nuclease resistance thus providing a molecule with high stability for example in human urine.
Mauro Comes franchini, E.L. (2024). MULTIFUNCTIONAL SYSTEM.
MULTIFUNCTIONAL SYSTEM
Mauro Comes franchini;Erica Locatelli;Silvia Tortorella;
2024
Abstract
The present invention is related to a multifunctional system bearing a ligand capable of recognizing 5 tumor cells or tumor-associated or inflammation-associated component and linked to a metal nanoparticle. More specifically, the multifunctional system of the invention comprises a nucleotide aptamer or a variant thereof that binds to the alpha 5 subunit of integrin and a metal nanoparticle, wherein said aptamer optionally comprises at least one modification capable of enhancing nuclease resistance thus providing a molecule with high stability for example in human urine.File in questo prodotto:
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