Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe infections in immunocompromised patients. During active infection, the virus is able to modulate the host immune system in immunocompetent as well as immunocompromised individuals. HCMV-infected patients often develop signs of immune dysfunction, such as autoimmune phenomena. Furthermore, case reports suggest a link between primary HCMV infection and onset of autoimmune disorders. Signs of active viral infection have also been identified in a number of autoimmune diseases, which further highlights the potential role of HCMV in the genesis and/or maintenance of immunopathological phenomena. Mechanisms by which HCMV could induce host immunopathology, inflammation and autoimmunity will be discussed as well as the opportunity to administer antivirals in selected patients.

Cytomegalovirus-induced autoimmunity

VARANI, STEFANIA;LANDINI, MARIA PAOLA;
2011

Abstract

Human cytomegalovirus (HCMV) is a ubiquitous pathogen that causes severe infections in immunocompromised patients. During active infection, the virus is able to modulate the host immune system in immunocompetent as well as immunocompromised individuals. HCMV-infected patients often develop signs of immune dysfunction, such as autoimmune phenomena. Furthermore, case reports suggest a link between primary HCMV infection and onset of autoimmune disorders. Signs of active viral infection have also been identified in a number of autoimmune diseases, which further highlights the potential role of HCMV in the genesis and/or maintenance of immunopathological phenomena. Mechanisms by which HCMV could induce host immunopathology, inflammation and autoimmunity will be discussed as well as the opportunity to administer antivirals in selected patients.
Autoimmune Disorders: Symptoms, Diagnosis and Treatment
205
227
Varani S.; Landini M.P.; Soderberg-Naucler C.
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/96532
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