Disclosed are compounds including rifamycin derivatives having antibacterial activities, wherein the compounds have the following general formula (I) wherein: R is hydrogen or acetyl R1 and R2 are independently selected from the group consisting of hydrogen, ( C1-4) alkyl, benzyloxy, mono- and di-(C1-3) alkylamino-(C1-4)alkyl, (C1-3)alkoxy, (C1-4) alkyl, hydroxy-methyl, hydroxy-(C2-4)-alkyl, and nitro or R1 and R2 taken together with two consecutive carbon atoms of the pyridine nucleus form a benzene ring optionally substituted by one or two methyl or ethyl groups and R3 is hydroxyalkyl (C1-4). In addition, processes to obtain these compounds are described. The compounds have antibacterial activity.
VISCOMI G. C., CAMPANA M., FOLEGATTI M., CANNATA V., RIGHI P., ROSINI G. (2010). RIFAMYCIN DERIVATIVES.
RIFAMYCIN DERIVATIVES
RIGHI, PAOLO;ROSINI, GOFFREDO
2010
Abstract
Disclosed are compounds including rifamycin derivatives having antibacterial activities, wherein the compounds have the following general formula (I) wherein: R is hydrogen or acetyl R1 and R2 are independently selected from the group consisting of hydrogen, ( C1-4) alkyl, benzyloxy, mono- and di-(C1-3) alkylamino-(C1-4)alkyl, (C1-3)alkoxy, (C1-4) alkyl, hydroxy-methyl, hydroxy-(C2-4)-alkyl, and nitro or R1 and R2 taken together with two consecutive carbon atoms of the pyridine nucleus form a benzene ring optionally substituted by one or two methyl or ethyl groups and R3 is hydroxyalkyl (C1-4). In addition, processes to obtain these compounds are described. The compounds have antibacterial activity.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
