Development of a HPLC with colulometric detection methodology to measure olanzapine (OLA) and 4-N-desmethylolanzapine (DMO) levels in specific areas of rat brain after a single dose of OLA. Preliminary results are satisfactory in terms of sensitivity and selectivity.
Chromatographic analysis of atypical antipsychotic olanzapine and its main metabolite in rat plasma and brain samples after chronic administration.
SARACINO, MARIA ADDOLORATA;RIMONDINI GIORGINI, ROBERTO;GHEDINI, NADIA;RAGGI, MARIA AUGUSTA
2010
Abstract
Development of a HPLC with colulometric detection methodology to measure olanzapine (OLA) and 4-N-desmethylolanzapine (DMO) levels in specific areas of rat brain after a single dose of OLA. Preliminary results are satisfactory in terms of sensitivity and selectivity.File in questo prodotto:
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