The use of single-cell technologies in characterizing the interactions between immune and cancer cells is in continuous expansion. Indeed, the combination of different single-cell approaches enables the definition of novel phenotypic and functional aspects of the immune cells infiltrating the tumor microenvironment (TME). This approach is promoting the discovery of relevant and reliable predictive biomarkers, along with the development of new promising treatments. In this chapter, we describe the main subsets of tumor-infiltrating lymphocytes from a phenotypical and functional point of view and discuss the use of single-cell technologies used to characterize these cell populations within TME.
Rebecca Borella, A.P. (2023). Multiparametric analysis of tumor infiltrating lymphocytes in solid tumors.. United States and United Kingdom : Kedar Narayan - National Institutes of Health, Bethesda, MD, United States Lucy Collinson - The Francis Crick Institute, London, United Kingdom Paul Verkade - University of Bristol, University Walk, Bristol, United Kingdom.
Multiparametric analysis of tumor infiltrating lymphocytes in solid tumors.
Beatrice AraminiWriting – Review & Editing
;
2023
Abstract
The use of single-cell technologies in characterizing the interactions between immune and cancer cells is in continuous expansion. Indeed, the combination of different single-cell approaches enables the definition of novel phenotypic and functional aspects of the immune cells infiltrating the tumor microenvironment (TME). This approach is promoting the discovery of relevant and reliable predictive biomarkers, along with the development of new promising treatments. In this chapter, we describe the main subsets of tumor-infiltrating lymphocytes from a phenotypical and functional point of view and discuss the use of single-cell technologies used to characterize these cell populations within TME.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
