Recent advances in the preparation of optically pure 1,2-diamines by stereoselective addition reactions to azomethine compounds (imines, iminium ions, oximes, hydrazones, nitrones). The methods scrutinized involve either the addition of carbon nucleophiles (organometallic reagents, carbanions, enolates, silyl enol ethers, carbon radicals and radical anions, too) to aldehyde derivatives, e.g. aldimines, and the complementary addition of hydrogen and hydride reagents to ketone derivatives, e.g. ketimines. Focus is given to the scope, advantages and limitations of the diverse methodologies and some possible developments are envisaged.

Progress in the Asymmetric Synthesis of 1,2-Diamines from Azomethine Compounds

SAVOIA, DIEGO
2005

Abstract

Recent advances in the preparation of optically pure 1,2-diamines by stereoselective addition reactions to azomethine compounds (imines, iminium ions, oximes, hydrazones, nitrones). The methods scrutinized involve either the addition of carbon nucleophiles (organometallic reagents, carbanions, enolates, silyl enol ethers, carbon radicals and radical anions, too) to aldehyde derivatives, e.g. aldimines, and the complementary addition of hydrogen and hydride reagents to ketone derivatives, e.g. ketimines. Focus is given to the scope, advantages and limitations of the diverse methodologies and some possible developments are envisaged.
Chiral Ligands for Asymmetric Synthesis
1
58
Savoia D.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/9207
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