IL-12 is a unique cytokine of 70 kD, composed of two covalently linked chains of 35 kD (p35) and 40 kD (p40) [1]. Although the single p40 chain is always produced in large excess over the p70 heterodimer, only the latter has biological activity and coexpression of both the p40 and the p35 genes in the same cells is required for the production of the biologically active p70 heterodimer [2]. IL-12 was originally identified in the cultured supernatant of Epstein-Barr virus (EBV)-transformed B-cell lines such as RPMI-8866 by virtue of its ability to activate NK cells and to induce production of IFN.
Ma XJ, AsteAmezaga M, Gri G, Gerosa F, Trinchieri G (1997). Immunomodulatory functions and molecular regulation of IL-12. Basel : KARGER [10.1159/000058687].
Immunomodulatory functions and molecular regulation of IL-12
Gri G;
1997
Abstract
IL-12 is a unique cytokine of 70 kD, composed of two covalently linked chains of 35 kD (p35) and 40 kD (p40) [1]. Although the single p40 chain is always produced in large excess over the p70 heterodimer, only the latter has biological activity and coexpression of both the p40 and the p35 genes in the same cells is required for the production of the biologically active p70 heterodimer [2]. IL-12 was originally identified in the cultured supernatant of Epstein-Barr virus (EBV)-transformed B-cell lines such as RPMI-8866 by virtue of its ability to activate NK cells and to induce production of IFN.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
