Cogan’s syndrome (CS) is a rare dis- ease, probably of organ-specific auto- immunity, likely triggered by an infection. • Typical CS is characterized by nonsyphi- litic interstitial keratitis associated with middle ear symptoms with progressive hearing loss. • CS becomes atypical in case of differ- ent type of eye and/or ear involve- ment or when the interval between the initial manifestations is longer than 2 years. • Systemic corticosteroids therapy is the most effective treatment especially in the presence of compromised auditory acuity. • The immediate steroid treatment can prevent hearing loss. • In case of failure or insufficient response to corticosteroids, immunomodulatory agents can be useful.
Cimino L, Fontana L, Salvarani C (2016). Cogan's syndrome. amsterdam : springer.
Cogan's syndrome
Fontana L;
2016
Abstract
Cogan’s syndrome (CS) is a rare dis- ease, probably of organ-specific auto- immunity, likely triggered by an infection. • Typical CS is characterized by nonsyphi- litic interstitial keratitis associated with middle ear symptoms with progressive hearing loss. • CS becomes atypical in case of differ- ent type of eye and/or ear involve- ment or when the interval between the initial manifestations is longer than 2 years. • Systemic corticosteroids therapy is the most effective treatment especially in the presence of compromised auditory acuity. • The immediate steroid treatment can prevent hearing loss. • In case of failure or insufficient response to corticosteroids, immunomodulatory agents can be useful.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
