The gut microbiome is recognized as an important component in determining the health status of ageing individuals due to its role in modulating digestive functions, immunity and resistance to pathogen infections, and cognitive functions. Microbial data from long-lived individuals showed the progressive transition to a peculiar elderly-type microbiome, often related to immunosenescence, inflammageing, and frailty, along with the emergence of some possibly ageing-supportive features. Here, we extensively describe the characteristics of such a microbiome configuration, with a focus on the concomitant ageing-associated unavoidable physiological modifications, in order to bring out the close connections between the human host and its microbial counterpart.
Ageing and Human Gut Microbiome: The Taxonomic and Functional Transition Towards an Elderly-Type Microbiome / Rampelli, Simone; Turroni, Silvia; Candela, Marco. - STAMPA. - 17:(2023), pp. 23-39. [10.1007/978-3-031-14023-5_2]
Ageing and Human Gut Microbiome: The Taxonomic and Functional Transition Towards an Elderly-Type Microbiome
Rampelli, Simone
;Turroni, Silvia;Candela, Marco
2023
Abstract
The gut microbiome is recognized as an important component in determining the health status of ageing individuals due to its role in modulating digestive functions, immunity and resistance to pathogen infections, and cognitive functions. Microbial data from long-lived individuals showed the progressive transition to a peculiar elderly-type microbiome, often related to immunosenescence, inflammageing, and frailty, along with the emergence of some possibly ageing-supportive features. Here, we extensively describe the characteristics of such a microbiome configuration, with a focus on the concomitant ageing-associated unavoidable physiological modifications, in order to bring out the close connections between the human host and its microbial counterpart.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
