Vitamin B12 deficiency is a common clinical condition, sometimes leading to severe hematologic and neurologic diseases. Screening for vitamin B12 deficiency is indicated in patients with relevant signs, such as anemia, neuropathy, or cognitive impairment. Since folic acid fortification started, the concern of masking anemia and macrocytosis due to vitamin B12 deficiency, leading to neurologic disease, has emerged. Oral treatment with vitamin B12 is effective even at low doses in most cases of food-bound vitamin B12 malabsorption, and it has been advocated as a suitable means to prevent B12 deficiencies. Fortification with vitamin B12 is expected to reduce the vitamin deficiency-related diseases and prevent the folic acid masking effect. It may also offer an opportunity to increase folic acid dose in fortified food. One of the major issues regarding food fortification with vitamin B12 is the awareness of the clinical conditions related to vitamin B12 deficiency and the potential of the replacement therapy to prevent them. More studies are needed to verify the appropriate dose and modality of vitamin B12 fortification and to examine safety and long-term outcomes. © 2011 Elsevier Inc. All rights reserved.
Agnoletti D., Zhang Y., Czernichow S., Galan P., Hercberg S., Safar M.E., et al. (2011). Fortification of Vitamin B12 to Flour and the Metabolic Response. 525 B STREET, SUITE 1900, SAN DIEGO, CA 92101-4495 USA : Elsevier Inc. [10.1016/B978-0-12-380886-8.10040-6].
Fortification of Vitamin B12 to Flour and the Metabolic Response
Agnoletti D.Primo
;
2011
Abstract
Vitamin B12 deficiency is a common clinical condition, sometimes leading to severe hematologic and neurologic diseases. Screening for vitamin B12 deficiency is indicated in patients with relevant signs, such as anemia, neuropathy, or cognitive impairment. Since folic acid fortification started, the concern of masking anemia and macrocytosis due to vitamin B12 deficiency, leading to neurologic disease, has emerged. Oral treatment with vitamin B12 is effective even at low doses in most cases of food-bound vitamin B12 malabsorption, and it has been advocated as a suitable means to prevent B12 deficiencies. Fortification with vitamin B12 is expected to reduce the vitamin deficiency-related diseases and prevent the folic acid masking effect. It may also offer an opportunity to increase folic acid dose in fortified food. One of the major issues regarding food fortification with vitamin B12 is the awareness of the clinical conditions related to vitamin B12 deficiency and the potential of the replacement therapy to prevent them. More studies are needed to verify the appropriate dose and modality of vitamin B12 fortification and to examine safety and long-term outcomes. © 2011 Elsevier Inc. All rights reserved.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
