Chloroethanes are widely produced and utilized compounds and have extensive human exposure. All of them are recognized as being toxic causing damage to the major parenchymous tissues, such as liver, kidney and central nervous system1. Some of them exert mutagenic activity in short-term tests in vitro but their carcinogenicity has not always been adequately evidenced2,3. These compounds require bioactivation to the proximate toxin or carcinogen via metabolism by cytochrome P450-dependent enzymatic systems forming adducts with the genetic material. In some instances, metabolism results in detoxication or inactivation of the bioactive metabolite to innocuous compound, generally through conjugation with GSH4. The aim of this study is to better identify the genotoxic activity of chloroethanes in in vivo and in vitro systems, also in an attempt to validate a cell-free system as a short-term test for carcinogenicity prediction of initiating compounds, and to find structure-activity relationships among compounds belonging to the same chemical class.
Grilli, S., Bartoli, S., Bonora, B., Colacci, A., Lattanzi, G., Mazzullo, M., et al. (1991). Genotoxicity of Chloroethanes and Structure-Activity Relationships. Boston, MA : Springer [10.1007/978-1-4615-3694-9_38].
Genotoxicity of Chloroethanes and Structure-Activity Relationships
Grilli, S.;Bartoli, S.;Bonora, B.;Colacci, A.;Mazzullo, M.;Perocco, P.;Turina, M. P.
1991
Abstract
Chloroethanes are widely produced and utilized compounds and have extensive human exposure. All of them are recognized as being toxic causing damage to the major parenchymous tissues, such as liver, kidney and central nervous system1. Some of them exert mutagenic activity in short-term tests in vitro but their carcinogenicity has not always been adequately evidenced2,3. These compounds require bioactivation to the proximate toxin or carcinogen via metabolism by cytochrome P450-dependent enzymatic systems forming adducts with the genetic material. In some instances, metabolism results in detoxication or inactivation of the bioactive metabolite to innocuous compound, generally through conjugation with GSH4. The aim of this study is to better identify the genotoxic activity of chloroethanes in in vivo and in vitro systems, also in an attempt to validate a cell-free system as a short-term test for carcinogenicity prediction of initiating compounds, and to find structure-activity relationships among compounds belonging to the same chemical class.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
