A decrease in extracellular calcium concentration ([Ca2+]o) leads to prolongation of action potential duration (APD) in ventricular cardiomyocytes and rate-corrected QT interval (QTc) in patients. Although this phenomenon is relevant to arrhythmogenesis in the clinical setting, its mechanisms are counterintuitive and incompletely understood. The aim of the present study was to identify the ionic mechanism/s likely to underlie the APD dependency on [Ca2+]o by using an in silico approach.

E. Grandi, C. Pes, C. Corsi, A. Zaza, S. Severi (2008). Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human ventricular myocytes. s.l : Patron Editore.

Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human ventricular myocytes

GRANDI, ELEONORA;CORSI, CRISTIANA;SEVERI, STEFANO
2008

Abstract

A decrease in extracellular calcium concentration ([Ca2+]o) leads to prolongation of action potential duration (APD) in ventricular cardiomyocytes and rate-corrected QT interval (QTc) in patients. Although this phenomenon is relevant to arrhythmogenesis in the clinical setting, its mechanisms are counterintuitive and incompletely understood. The aim of the present study was to identify the ionic mechanism/s likely to underlie the APD dependency on [Ca2+]o by using an in silico approach.
2008
Atti del Primo Congresso Nazionale di Bioingegneria
183
184
E. Grandi, C. Pes, C. Corsi, A. Zaza, S. Severi (2008). Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human ventricular myocytes. s.l : Patron Editore.
E. Grandi; C. Pes; C. Corsi; A. Zaza; S. Severi
File in questo prodotto:
Eventuali allegati, non sono esposti

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/88382
 Attenzione

Attenzione! I dati visualizzati non sono stati sottoposti a validazione da parte dell'ateneo

Citazioni
  • ???jsp.display-item.citation.pmc??? ND
  • Scopus ND
  • ???jsp.display-item.citation.isi??? ND
social impact