A decrease in extracellular calcium concentration ([Ca2+]o) leads to prolongation of action potential duration (APD) in ventricular cardiomyocytes and rate-corrected QT interval (QTc) in patients. Although this phenomenon is relevant to arrhythmogenesis in the clinical setting, its mechanisms are counterintuitive and incompletely understood. The aim of the present study was to identify the ionic mechanism/s likely to underlie the APD dependency on [Ca2+]o by using an in silico approach.

Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human ventricular myocytes

GRANDI, ELEONORA;CORSI, CRISTIANA;SEVERI, STEFANO
2008

Abstract

A decrease in extracellular calcium concentration ([Ca2+]o) leads to prolongation of action potential duration (APD) in ventricular cardiomyocytes and rate-corrected QT interval (QTc) in patients. Although this phenomenon is relevant to arrhythmogenesis in the clinical setting, its mechanisms are counterintuitive and incompletely understood. The aim of the present study was to identify the ionic mechanism/s likely to underlie the APD dependency on [Ca2+]o by using an in silico approach.
2008
Atti del Primo Congresso Nazionale di Bioingegneria
183
184
E. Grandi; C. Pes; C. Corsi; A. Zaza; S. Severi
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/88382
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