In accordance with a first aspect of the present invention, it is provided a method for the preparation of an active nanoparticle, comprising a mixing step, during which at least one active compound is mixed with molecules of at least one surfactant in an organic solvent; an evaporation step, that is subsequent to the mixing step and during which the organic solvent is evaporated in order to obtain a residue; a reaction step, which is subsequent to the evaporation step and during which molecules of at least one alkoxysilane are added to the residue and silanized in presence of water; the alkoxysilane is chosen between a tetraalkoxysilane and a trialkoxysilane; the surfactant comprising the following structure: Hydro1-Lipo-Hydro2 wherein Lipo indicates a substantially hydrophobic chain, Hydro1 and Hydro2 each indicate a substantially hydrophilic chain. Advantageously, the active compound is substantially lipophilic.

Active Particles for Bio-Analytical Applications and Methods for Preparation Thereof

BONACCHI, SARA;JURIS, RICCARDO;MONTALTI, MARCO;PRODI, LUCA;RAMPAZZO, ENRICO;ZACCHERONI, NELSI
2009

Abstract

In accordance with a first aspect of the present invention, it is provided a method for the preparation of an active nanoparticle, comprising a mixing step, during which at least one active compound is mixed with molecules of at least one surfactant in an organic solvent; an evaporation step, that is subsequent to the mixing step and during which the organic solvent is evaporated in order to obtain a residue; a reaction step, which is subsequent to the evaporation step and during which molecules of at least one alkoxysilane are added to the residue and silanized in presence of water; the alkoxysilane is chosen between a tetraalkoxysilane and a trialkoxysilane; the surfactant comprising the following structure: Hydro1-Lipo-Hydro2 wherein Lipo indicates a substantially hydrophobic chain, Hydro1 and Hydro2 each indicate a substantially hydrophilic chain. Advantageously, the active compound is substantially lipophilic.
PCT/IB2009/006432
S. Bonacchi; R. Juris; M. Montalti; L. Prodi; E. Rampazzo; N. Zaccheroni
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/11585/84265
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