The modification of infectivity of different animal chlamydial species after their in vitro treatment with 10 and 80 µg/ml of PG-1 peptide, was studied. PG-1 at 10 µg/ml concentration had neither inhibitory nor increasing effects on the infectivity of all Chlamydia tested, whereas the incubation of 80 µg/ml of PG-1 with C. suis and Cp. pecorum isolates resulted in a twofold increase in the number of inclusions; a five- to tenfold increase in chlamydial infectivity was observed when Cp. psittaci and Cp. abortus strains were tested with the concentration of 80 µg/ml of PG-1 peptide. On the contrary, C. muridarum strain and Cp.felis isolates did not show any increase in the number of inclusions when incubated with PG-1 at a 80 µg/ml concentration. The different effect of PG-1 on the animals strains of chlamydiae could be due to the unique characteristics in the membrane structure of each strain.

Increasing effect of high dose of PG-1 peptide on the infectivity of different animal species of Chlamydia.

DONATI, MANUELA;DI FRANCESCO, ANTONIETTA;BALDELLI, RAFFAELLA;CEVENINI, ROBERTO
2009

Abstract

The modification of infectivity of different animal chlamydial species after their in vitro treatment with 10 and 80 µg/ml of PG-1 peptide, was studied. PG-1 at 10 µg/ml concentration had neither inhibitory nor increasing effects on the infectivity of all Chlamydia tested, whereas the incubation of 80 µg/ml of PG-1 with C. suis and Cp. pecorum isolates resulted in a twofold increase in the number of inclusions; a five- to tenfold increase in chlamydial infectivity was observed when Cp. psittaci and Cp. abortus strains were tested with the concentration of 80 µg/ml of PG-1 peptide. On the contrary, C. muridarum strain and Cp.felis isolates did not show any increase in the number of inclusions when incubated with PG-1 at a 80 µg/ml concentration. The different effect of PG-1 on the animals strains of chlamydiae could be due to the unique characteristics in the membrane structure of each strain.
Proceedings of the First European Meeting on Animal Chlamydioses and Zoonotic Aspects.
36
36
Donati M.; Di Francesco A.; Delucca F.; Shurdi A.; Gennaro R.; Benincasa M.; Baldelli R.; Cevenini R.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/84135
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