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EnglishThe modification of infectivity of different animal chlamydial species after their in vitro treatment with 10 and 80 µg/ml of PG-1 peptide, was studied. PG-1 at 10 µg/ml concentration had neither inhibitory nor increasing effects on the infectivity of all Chlamydia tested, whereas the incubation of 80 µg/ml of PG-1 with C. suis and Cp. pecorum isolates resulted in a twofold increase in the number of inclusions; a five- to tenfold increase in chlamydial infectivity was observed when Cp. psittaci and Cp. abortus strains were tested with the concentration of 80 µg/ml of PG-1 peptide. On the contrary, C. muridarum strain and Cp.felis isolates did not show any increase in the number of inclusions when incubated with PG-1 at a 80 µg/ml concentration. The different effect of PG-1 on the animals strains of chlamydiae could be due to the unique characteristics in the membrane structure of each strain.
| Titolo: | Increasing effect of high dose of PG-1 peptide on the infectivity of different animal species of Chlamydia. |
| Autore/i: | DONATI, MANUELA; DI FRANCESCO, ANTONIETTA; Delucca F.; Shurdi A.; Gennaro R.; Benincasa M.; BALDELLI, RAFFAELLA; CEVENINI, ROBERTO |
| Autore/i Unibo: | |
| Anno: | 2009 |
| Titolo del libro: | Proceedings of the First European Meeting on Animal Chlamydioses and Zoonotic Aspects. |
| Pagina iniziale: | 36 |
| Pagina finale: | 36 |
| Abstract: | The modification of infectivity of different animal chlamydial species after their in vitro treatment with 10 and 80 µg/ml of PG-1 peptide, was studied. PG-1 at 10 µg/ml concentration had neither inhibitory nor increasing effects on the infectivity of all Chlamydia tested, whereas the incubation of 80 µg/ml of PG-1 with C. suis and Cp. pecorum isolates resulted in a twofold increase in the number of inclusions; a five- to tenfold increase in chlamydial infectivity was observed when Cp. psittaci and Cp. abortus strains were tested with the concentration of 80 µg/ml of PG-1 peptide. On the contrary, C. muridarum strain and Cp.felis isolates did not show any increase in the number of inclusions when incubated with PG-1 at a 80 µg/ml concentration. The different effect of PG-1 on the animals strains of chlamydiae could be due to the unique characteristics in the membrane structure of each strain. |
| Data prodotto definitivo in UGOV: | 23-feb-2010 |
| Appare nelle tipologie: | 4.02 Riassunto (Abstract) |
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