Described are compounds, which are antagonists of the P2Y14 receptor, for example, a compound of formula (I) in which ring A, R1,R2, R3, and n are as described herein. Also provided are dendron conjugates comprising the compounds, and methods of using the compounds, including a method of treating a disorder, such as inflammation, diabetes, insulin resistance, hyperglycemia, a lipid disorder, obesity, a condition associated with metabolic syndrome, and asthma, and a method of antagonizing P214 receptor activity in a cell.

Kenneth A. Jacobson, A.J. (2016). Triazole derivatives as P2Y14 receptor antagonists.

Triazole derivatives as P2Y14 receptor antagonists

Elisa Uliassi;
2016

Abstract

Described are compounds, which are antagonists of the P2Y14 receptor, for example, a compound of formula (I) in which ring A, R1,R2, R3, and n are as described herein. Also provided are dendron conjugates comprising the compounds, and methods of using the compounds, including a method of treating a disorder, such as inflammation, diabetes, insulin resistance, hyperglycemia, a lipid disorder, obesity, a condition associated with metabolic syndrome, and asthma, and a method of antagonizing P214 receptor activity in a cell.
2016
US10683277B2
Kenneth A. Jacobson, A.J. (2016). Triazole derivatives as P2Y14 receptor antagonists.
Kenneth A. Jacobson, Anna Junker, Elisa Uliassi, Evgeny Kiselev
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/801578
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