Opioids play a pivotal role in pain transmission but are also able to modulate immune cell functions. In the last decades a connection between opioids and integrins—adhesion molecules involved, among many other processes, in leukocyte recruitment at inflamed site—has been established. To study immune cell integrin-mediated adhesion, cell adhesion assay is a simple, reproducible, and valuable tool capable of unraveling concentration-dependent effects of a test candidate on integrin-mediated cell adhesion.
Baiula M. (2021). An in vitro assay to study the role of opioids in modulating immune cell adhesion. New York : Humana Press Inc. [10.1007/978-1-0716-0884-5_14].
An in vitro assay to study the role of opioids in modulating immune cell adhesion
Baiula M.Primo
2021
Abstract
Opioids play a pivotal role in pain transmission but are also able to modulate immune cell functions. In the last decades a connection between opioids and integrins—adhesion molecules involved, among many other processes, in leukocyte recruitment at inflamed site—has been established. To study immune cell integrin-mediated adhesion, cell adhesion assay is a simple, reproducible, and valuable tool capable of unraveling concentration-dependent effects of a test candidate on integrin-mediated cell adhesion.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
