Tumorigenesis of biliopancreatic lesions is linked to specific alterations in key genes. Pancreatic neoplasms are well characterized at the genomic level. For example, exome and genome sequencing analyses revealed that pancreatic adenonocarcinomas are characterized by mutations manly in KRAS, TP53, CDKN2A/p16, and SMAD4 genes. Nevertheless, the pre-operative diagnosis and the management of patients with biliopancreatic lesion are still a clinical challenge, involving not only the endoscopic ultrasound-guided fine-needle aspiration procedure but also the appropriate biomolecular assessment of these lesions. The aim of the present chapter is to provide an overview of the current knowledge of the biology of biliopancreatic lesions as detected by molecular techniques.

Visani M., Acquaviva G., Pession A., Tallini G., de Biase D. (2020). Molecular biology of biliopancreatic lesions. New York City : Springer International Publishing [10.1007/978-3-030-42569-2_51].

Molecular biology of biliopancreatic lesions

Visani M.;Acquaviva G.;Pession A.;Tallini G.;de Biase D.
2020

Abstract

Tumorigenesis of biliopancreatic lesions is linked to specific alterations in key genes. Pancreatic neoplasms are well characterized at the genomic level. For example, exome and genome sequencing analyses revealed that pancreatic adenonocarcinomas are characterized by mutations manly in KRAS, TP53, CDKN2A/p16, and SMAD4 genes. Nevertheless, the pre-operative diagnosis and the management of patients with biliopancreatic lesion are still a clinical challenge, involving not only the endoscopic ultrasound-guided fine-needle aspiration procedure but also the appropriate biomolecular assessment of these lesions. The aim of the present chapter is to provide an overview of the current knowledge of the biology of biliopancreatic lesions as detected by molecular techniques.
2020
Endotherapy in Biliopancreatic Diseases: ERCP Meets EUS: Two Techniques for One Vision
569
577
Visani M., Acquaviva G., Pession A., Tallini G., de Biase D. (2020). Molecular biology of biliopancreatic lesions. New York City : Springer International Publishing [10.1007/978-3-030-42569-2_51].
Visani M.; Acquaviva G.; Pession A.; Tallini G.; de Biase D.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/11585/783066
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