Nuclear inositides have a specific subcellular distribution that is linked to specific functions; thus their regulation is fundamental both in health and disease. Emerging evidence shows that alterations in multiple inositide signalling pathways are involved in pathophysiology, not only in cancer but also in other diseases. Here, we give an overview of the main features of inositides in the cell, and we discuss their potential as new molecular therapeutic targets.
Inositide-Dependent Nuclear Signalling in Health and Disease / Follo M.Y.; Ratti S.; Manzoli L.; Ramazzotti G.; Faenza I.; Fiume R.; Mongiorgi S.; Suh P.G.; McCubrey J.A.; Cocco L.. - STAMPA. - 259:(2020), pp. 291-308. [10.1007/164_2019_321]
Inositide-Dependent Nuclear Signalling in Health and Disease
Follo M. Y.;Ratti S.;Manzoli L.;Ramazzotti G.;Faenza I.;Fiume R.;Mongiorgi S.;Cocco L.
2020
Abstract
Nuclear inositides have a specific subcellular distribution that is linked to specific functions; thus their regulation is fundamental both in health and disease. Emerging evidence shows that alterations in multiple inositide signalling pathways are involved in pathophysiology, not only in cancer but also in other diseases. Here, we give an overview of the main features of inositides in the cell, and we discuss their potential as new molecular therapeutic targets.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
