The effect of amphiphlic non-steroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen (Ibu) a white insoluble powder pKa = 4,31 on liposomal bilayer as biomembrane model, plays a crucial role in understanding their mechanism at the molecular level. To explain their activity and correlate it with the chemico-physical properties of the drug, the thermal behaviour of the hydrated multilamellar vesicles (liposomes) of dimyristoylphosphatidylcholine (DMPC) in the presence of increasing amounts of both Ibu as well of its Na-salt (Na-Ibu) have been studied at pH = 3.0 and at pH = 7.0 by means of Differential Scanning Calorimetry (DSC) technique.
M. Di Foggia, S. Bonora, A. Torreggiani (2008). Effect of Ibuprofen on the thermal behaviour of DMPC liposomes as a function of pH.. FIRENZE : Firenze University Press.
Effect of Ibuprofen on the thermal behaviour of DMPC liposomes as a function of pH.
DI FOGGIA, MICHELE;BONORA, SERGIO;
2008
Abstract
The effect of amphiphlic non-steroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen (Ibu) a white insoluble powder pKa = 4,31 on liposomal bilayer as biomembrane model, plays a crucial role in understanding their mechanism at the molecular level. To explain their activity and correlate it with the chemico-physical properties of the drug, the thermal behaviour of the hydrated multilamellar vesicles (liposomes) of dimyristoylphosphatidylcholine (DMPC) in the presence of increasing amounts of both Ibu as well of its Na-salt (Na-Ibu) have been studied at pH = 3.0 and at pH = 7.0 by means of Differential Scanning Calorimetry (DSC) technique.I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.
